II. Dosing

  1. Amenorrhea
    1. Sequential: 5 to 10 mg qd for 5-10 days
    2. Continuous: 2.5 mg qd
  2. Dysfunctional Uterine Bleeding (DUB)
    1. Sequential: 5-10 mg qd for 5-10 days, start on Day 16
  3. Postmenopausal Estrogen Replacement (with Premarin)
    1. Sequential: 2.5 to 5 mg PO qd for last 10 cycle days
    2. Continuous: 5 to 10 mg qd

III. Adverse effects

  1. Major Depression
  2. Breakthrough bleeding
    1. Increasing dose to 20-30 mg qd may reduce bleeding
      1. However may have increased risk
      2. Long term lipid and cardiovascular effects?

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Cost: Medications

Medroxyprogesterone Acetate (on 6/18/2017 at Walmart.com)
Medroxyprogesterone Acetate 10mg #10 tablets for $4.00 $0.40 each
Medroxyprogesterone Acetate 10mg #30 tablets for $10.00 $0.33 each
Medroxyprogesterone Acetate 2.5mg #30 tablets for $4.00 $0.13 each
Medroxyprogesterone Acetate 2.5mg #90 tablets for $10.00 $0.11 each
Medroxyprogesterone Acetate 5mg #30 tablets for $4.00 $0.13 each
Medroxyprogesterone Acetate 5mg #90 tablets for $10.00 $0.11 each
medroxyprogesterone (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
MEDROXYPROGESTERONE 10 MG TAB Generic $0.15 each
MEDROXYPROGESTERONE 150 MG/ML Generic $69.86 per ml
MEDROXYPROGESTERONE 2.5 MG TAB Generic $0.13 each
MEDROXYPROGESTERONE 5 MG TAB Generic $0.13 each

Ontology: Medroxyprogesterone (C0025147)

Definition (NCI) A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. (NCI04)
Definition (NCI_NCI-GLOSS) A hormonal anticancer drug that is also used in cancer prevention. It belongs to the family of drugs called progestins.
Definition (MSH) (6 alpha)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione. A synthetic progestational hormone used in veterinary practice as an estrus regulator.
Definition (CSP) synthetic progestin derived from 17-hydroxyprogesterone; a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
Definition (PDQ) A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39813&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39813&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C629" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Hormone (T125) , Steroid (T110)
MSH D008525
SnomedCT 36621009, 126113007, 27707001
English 17 alpha-Hydroxy-6 alpha-Methylprogesterone, Methylhydroxyprogesterone, 17 alpha Hydroxy 6 alpha Methylprogesterone, Pregn-4-ene-3,20-dione, 17-hydroxy-6-methyl-, (6alpha)-, 17Alpha-hydroxy-6alpha-methylprogesterone, 6Alpha-methyl-17alpha-hydroxyprogesterone, 6Alpha-methyl-4-pregnen-17alpha-ol-3,20-dione, (6Alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione, Medroxyprogesterone [Chemical/Ingredient], medroxyPROGESTERone, MEDROXYPROGESTERONE, medroxyprogesterone, Medroxyprogesterone preparation, Medroxyprogesterone (substance), Medroxyprogesterone preparation (product), MPA, Medroxyprogesterone acetate preparation (substance), Medroxyprogesterone preparation (substance), Medroxyprogesterone
Swedish Medroxiprogesteron
Czech medroxyprogesteron
Finnish Medroksiprogesteroni
Russian MEDROKSIPROGESTERON, METIPREGNON, METILGIDROKSIPROGESTERON, МЕДРОКСИПРОГЕСТЕРОН, МЕТИЛГИДРОКСИПРОГЕСТЕРОН, МЕТИПРЕГНОН
Japanese メチルヒドロキシプロゲステロン, メドロキシプロゲステロン
Spanish preparado con medroxiprogesterona (producto), medroxiprogesterona (producto), preparado con medroxiprogesterona, medroxiprogesterona (sustancia), medroxiprogesterona, preparado de medroxiprogesterona (producto), preparado de medroxiprogesterona (sustancia), preparado de medroxiprogesterona, Medroxiprogesterona, Metilhidroxiprogesterona
Croatian MEDROKSIPROGESTERON
Polish Medroksyprogesteron
French Médroxyprogestérone
German Medroxyprogesteron, Methylhydroxyprogesteron
Italian Medrossiprogesterone
Portuguese Medroxiprogesterona, Metilidroxiprogesterona

Ontology: Provera (C0699702)

Definition (CHV) brand name of a synthetic female sex hormone
Definition (CHV) brand name of a synthetic female sex hormone
Concepts Pharmacologic Substance (T121) , Steroid (T110)
MSH D017258
English provera, provera [brand name], Provera
Czech Provera