II. Dosing

  1. Amenorrhea
    1. Sequential: 5 to 10 mg qd for 5-10 days
    2. Continuous: 2.5 mg qd
  2. Dysfunctional Uterine Bleeding (DUB)
    1. Sequential: 5-10 mg qd for 5-10 days, start on Day 16
  3. Postmenopausal Estrogen Replacement (with Premarin)
    1. Sequential: 2.5 to 5 mg PO qd for last 10 cycle days
    2. Continuous: 5 to 10 mg qd

III. Adverse effects

  1. Major Depression
  2. Breakthrough bleeding
    1. Increasing dose to 20 to 30 mg daily may reduce bleeding
      1. However may have increased risk
      2. Long term lipid and cardiovascular effects?

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Related Studies

Cost: Medications

medroxyprogesterone (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
MEDROXYPROGESTERONE 10 MG TAB Generic $0.14 each
MEDROXYPROGESTERONE 150 MG/ML Generic $27.39 per ml
MEDROXYPROGESTERONE 2.5 MG TAB Generic $0.11 each
MEDROXYPROGESTERONE 5 MG TAB Generic $0.13 each