II. Indications

  1. Narcolepsy
  2. Non-FDA approved use
    1. Attention Deficit Hyperactivity Disorder
    2. Fatigue in Multiple Sclerosis
    3. Excessive Sleepiness in myotonic dystrophy

III. Contraindications (relative)

  1. Coronary Artery Disease
  2. Hypertension
  3. Other cardiovascular disease

IV. Mechanism

  1. Stimulant

V. Dosing: Adults

  1. ADHD: 100-300 mg PO qd (Not FDA approved)
  2. Narcolepsy: 200 mg qAM

VI. Dosing: Children Age >5 years

  1. ADHD: 50-100 mg PO qd (Not FDA approved)

VII. Efficacy: Narcolepsy

  1. May be slightly less effective then agents above
  2. Less addictive potential then agents above
  3. (1999) Med Lett Drugs Ther 41(1049):30-2 [PubMed]

VIII. Efficacy: ADHD

IX. Adverse Effects

  1. Headache
  2. Nervousness
  3. Dizziness
  4. Depressed mood
  5. Anxiety
  6. Cataplexy
  7. Insomnia
  8. Diarrhea
  9. Nausea
  10. Xerostomia
  11. Anorexia
  12. Paresthesias
  13. Pharyngitis or Rhinitis

X. References

  1. (2003) Lexi-Comp Drug Database for Pocket PC (7/9/03)

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Cost: Medications

modafinil (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
MODAFINIL 100 MG TABLET Generic $2.91 each
MODAFINIL 200 MG TABLET Generic $3.16 each
provigil (on 1/1/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
PROVIGIL 100 MG TABLET Generic $2.91 each
PROVIGIL 200 MG TABLET Generic $3.16 each

Ontology: modafinil (C0066677)

Definition (NCI) A synthetic central nervous system stimulant with wakefulness-promoting activity. Modafinil appears to inhibit dopamine reuptake, resulting in an increase in extracellular dopamine. This agent exhibits pronounced wakefulness-promoting activity (without sympathomimetic activity) and may improve cognitive function in certain clinical settings. (NCI04)
Definition (NCI_NCI-GLOSS) A drug that is being studied as a treatment for fatigue in patients with cancer. It belongs to the family of drugs called stimulants.
Definition (PDQ) A synthetic central nervous system stimulant with wakefulness-promoting activity. Modafinil appears to inhibit dopamine reuptake, resulting in an increase in extracellular dopamine. This agent exhibits pronounced wakefulness-promoting activity (without sympathomimetic activity) and may improve cognitive function in certain clinical settings. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=256449&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=256449&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26661" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C048833
SnomedCT 116082007, 387004007
LNC LP66956-1, MTHU028053
English benzhydrylsulfinylacetamide, modafinil, modafinil (medication), MODAFINIL, modafinil [Chemical/Ingredient], 2-((diphenylmethyl)sulfinyl)acetamide, Modafinil, Modafinil (product), Modafinil (substance)
Spanish modafinilo, modafinilo (producto), modafinil, modafinilo (sustancia), modafinil (producto), modafinil (sustancia)

Ontology: Provigil (C0722882)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C048833
English Provigil, modafinil (Provigil), provigil, Cephalon brand of modafinil