Mental Health Book

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ModafinilAka: Provigil

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  1. Indications
    1. Narcolepsy
    2. Non-FDA approved use
      1. Attention Deficit Hyperactivity Disorder
      2. Fatigue in Multiple Sclerosis
      3. Excessive Sleepiness in myotonic dystrophy
  2. Contraindications (relative)
    1. Coronary Artery Disease
    2. Hypertension
    3. Other cardiovascular disease
  3. Mechanism
    1. Stimulant
  4. Dosing: Adults
    1. ADHD: 100-300 mg PO qd (Not FDA approved)
    2. Narcolepsy: 200 mg qAM
  5. Dosing: Children Age >5 years
    1. ADHD: 50-100 mg PO qd (Not FDA approved)
  6. Efficacy: Narcolepsy
    1. May be slightly less effective then agents above
    2. Less addictive potential then agents above
    3. (1999) Med Lett Drugs Ther 41(1049):30
  7. Efficacy: ADHD
    1. Only small studies to show effectiveness and safety
    2. References
      1. Rugino (2001) J Am Acad Child Adolesc Psychiatry :
      2. Taylor (2000) J Child Adolesc Psychopharmacol 10:311
  8. Adverse Effects
    1. Headache
    2. Nervousness
    3. Dizziness
    4. Depressed mood
    5. Anxiety
    6. Cataplexy
    7. Insomnia
    8. Diarrhea
    9. Nausea
    10. Xerostomia
    11. Anorexia
    12. Paresthesias
    13. Pharyngitis or Rhinitis
  9. References
    1. (2003) Lexi-Comp Drug Database for Pocket PC (7/9/03)

modafinil (C0066677)

Definition (NCI)A drug that is being studied as a treatment for fatigue in patients with cancer. It belongs to the family of drugs called stimulants.
Definition (PDQ)A synthetic central nervous system stimulant with wakefulness-promoting activity. Modafinil appears to inhibit dopamine reuptake, resulting in an increase in extracellular dopamine. This agent exhibits pronounced wakefulness-promoting activity (without sympathomimetic activity) and may improve cognitive function in certain clinical settings. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=256449&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=256449&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26661" NCI Thesaurus)
Definition (NCI)A synthetic central nervous system stimulant with wakefulness-promoting activity. Modafinil appears to inhibit dopamine reuptake, resulting in an increase in extracellular dopamine. This agent exhibits pronounced wakefulness-promoting activity (without sympathomimetic activity) and may improve cognitive function in certain clinical settings. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC048833
Englishbenzhydrylsulfinylacetamide, modafinil, MODAFINIL PREPARATION
Spanishmodafinil
Parent ConceptsMiscellaneous Adjuvant (C1513319), Benzhydryl Compounds (C0005046), Other central nervous system stimulants (C0731742), Central Nervous System Stimulants (C0002763), Analeptics (C0242181), Drug allergen (C1320237), Non-amphetamines (C1579270)
SourcesMSH, MTHSPL, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Provigil (C0722882)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC048833
EnglishCephalon brand of modafinil, Provigil
SourcesMSH, NCI, PDQ, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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