Mental Health Book

Anxiety Disorders

Bipolar Disorder

Chemical Dependency

Depression

Psychosis

Sexual Development

Sleep Disorders

Obstetrics Chapter related topics

http://www.fpnotebook.com/

Modafinil

Aka: Modafinil, Provigil
  1. Indications
    1. Narcolepsy
    2. Non-FDA approved use
      1. Attention Deficit Hyperactivity Disorder
      2. Fatigue in Multiple Sclerosis
      3. Excessive Sleepiness in myotonic dystrophy
  2. Contraindications (relative)
    1. Coronary Artery Disease
    2. Hypertension
    3. Other cardiovascular disease
  3. Mechanism
    1. Stimulant
  4. Dosing: Adults
    1. ADHD: 100-300 mg PO qd (Not FDA approved)
    2. Narcolepsy: 200 mg qAM
  5. Dosing: Children Age >5 years
    1. ADHD: 50-100 mg PO qd (Not FDA approved)
  6. Efficacy: Narcolepsy
    1. May be slightly less effective then agents above
    2. Less addictive potential then agents above
    3. (1999) Med Lett Drugs Ther 41(1049):30-2
  7. Efficacy: ADHD
    1. Only small studies to show effectiveness and safety
    2. References
      1. Rugino (2001) J Am Acad Child Adolesc Psychiatry 40
      2. Taylor (2000) J Child Adolesc Psychopharmacol 10:311
  8. Adverse Effects
    1. Headache
    2. Nervousness
    3. Dizziness
    4. Depressed mood
    5. Anxiety
    6. Cataplexy
    7. Insomnia
    8. Diarrhea
    9. Nausea
    10. Xerostomia
    11. Anorexia
    12. Paresthesias
    13. Pharyngitis or Rhinitis
  9. References
    1. (2003) Lexi-Comp Drug Database for Pocket PC (7/9/03)

modafinil (C0066677)

Definition (NCI) A synthetic central nervous system stimulant with wakefulness-promoting activity. Modafinil appears to inhibit dopamine reuptake, resulting in an increase in extracellular dopamine. This agent exhibits pronounced wakefulness-promoting activity (without sympathomimetic activity) and may improve cognitive function in certain clinical settings. (NCI04)
Definition (NCI) A drug that is being studied as a treatment for fatigue in patients with cancer. It belongs to the family of drugs called stimulants.
Definition (PDQ) A synthetic central nervous system stimulant with wakefulness-promoting activity. Modafinil appears to inhibit dopamine reuptake, resulting in an increase in extracellular dopamine. This agent exhibits pronounced wakefulness-promoting activity (without sympathomimetic activity) and may improve cognitive function in certain clinical settings. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=256449&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=256449&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26661" NCI Thesaurus)
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C048833
SnomedCT 116082007, 387004007
English benzhydrylsulfinylacetamide, modafinil, modafinil (medication), MODAFINIL, modafinil [Chemical/Ingredient], Modafinil, Modafinil (product), Modafinil (substance)
Spanish modafinilo, modafinilo (producto), modafinil, modafinilo (sustancia), modafinil (producto), modafinil (sustancia)
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Provigil (C0722882)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C048833
English Provigil, modafinil (Provigil), provigil, Cephalon brand of modafinil
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Navigation Tree