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SuccinylcholineAka: Suxamethonium Chloride, Anectine
- See Also
- Precautions
- Used only in anesthesia, emergency and intensive care
- Airway and respiratory control is critical after use
- Paralytic Agents do not alter Level of Consciousness
- Must be used with Sedation and analgesia
- Indication
- Paralysis in Rapid Sequence Intubation
- Contraindications
- Hyperkalemia
- Myopathy with elevated Creatine Phosphokinase
- Malignant hyperthermia history or Family History
- Penetrating Eye Injury
- Narrow Angle Glaucoma
- Increased Intracranial Pressure
- Congestive Heart Failure
- Mechanism
- Depolarizing Neuromuscular Blocking Agent (prototype)
- Dose (based on ideal body weight in obese patients)
- Initial dose
- IV Dose: 1-1.5 mg/kg up to 150 mg IV
- IM Dose: 2-4 mg/kg up to 150 mg IM
- Raise dose if used with non-depolarizing agent
- Maintenance dosing (if needed)
- Starts 5-10 minutes after initial dose
- Please see other references for maintenance dosing
- May be used as a continuous infusion
- Initial dose
- Pharmacokinetics
- Onset: <1 minute
- Duration: 4-6 minute
- Adverse Effects
- Bradycardia
- Hyperkalemia
- Masseter muscle spasm
- Malignant hyperthermia
- Increased Intracranial Pressure
- References
- Miller in Katzung (1989) Pharmacology, p. 323-33
- Savarese in Miller (2000) Anesthesia, p. 412-90
- (2003) Lexicomp Drug database for Pocket PC
Succinylcholine (C0038627) | |
|---|---|
| Definition (MSH) | A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D013390 |
| English | Succinylcholine, SUCCINYLCHOLINE PREPARATION, Succinyldicholine, Suxamethonium |
| Spanish | succinilcolina, suxametonio |
| Parent Concepts | Choline (C0008405), Succinates (C0038617), Muscle relaxants (C0358430), Neuromuscular Blocking Agents (C0027866), Neuromuscular Depolarizing Agents (C0027867), Drug allergen by structure (C1532645), Skeletal Muscle Relaxants (C0037250) |
| Sources | AOD, CSP, LNC, MSH, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF Derived from the NIH UMLS (Unified Medical Language System) |
Anectine (C0700978) | |
|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D013390 |
| English | Anectine |
| Sources | AOD, MSH, NCI, RXNORM Derived from the NIH UMLS (Unified Medical Language System) |
