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Transdermal EstrogenAka: Estraderm, Estrasorb, Topical Estradiol, Evanmist, Estrogel, Elestrin, Divigel
- Indications
- Osteoporosis Prevention in postmenopausal women (Estraderm or Estrasorb)
- Hot Flashes (Evanmist, Estrogel, Elestrin, Divigel)
- Advantages
- Studies suggest no increased thromboembolism risk
- Efficacy: Osteoporosis Prevention (Estraderm or Estrasorb)
- Placebo
- Hip BMD: 2.04% loss
- Lumbar spine BMD: 2.49% loss
- Dose: 0.025 mg estradiol patch
- Hip BMD: 0.26% gain
- Lumbar spine BMD: 2.37% gain
- Dose: 0.05 mg estradiol patch
- Hip BMD: 2.85% gain
- Lumbar spine BMD: 4.09% gain
- Dose: 0.06 mg estradiol patch
- Hip BMD: 3.05% gain
- Lumbar spine BMD: 3.28% gain
- Dose: 0.1 mg estradiol patch
- Hip BMD: 2.03% gain
- Lumbar spine BMD: 4.70% gain
- References
- Placebo
- Preparations: Agents used for Osteoporosis
- Estrasorb (Transdermal Estradiol)
- Two foil packs equivalent to 0.05 mg Estradiol
- Rub one packet on right top of thigh, back of calf
- Repeat with second packet on left leg
- Do not apply with Sunscreen (increases absorption)
- Estraderm (Transdermal Estradiol Patch) 0.05 mg
- Must be taken with Provera if uterus intact
- Apply to non-irritated skin
- Lower abdomen
- Buttock
- Do not apply to breast
- Change patch twice weekly using a different site
- Estrasorb (Transdermal Estradiol)
- Preparations: Agents used for Hot Flashes (Topical Estradiol)
- Evanmist
- Dosing: 1-3 sprays per day on inner forearm to adjacent areas (not overlapping)
- Allow skin to dry for 30 minutes
- Estrogel (0.06% estradiol)
- Pump delivers 0.75 mg of estradiol (64 actuations per device)
- Apply gel from one wrist to the shoulder, spreading thinly
- Elestrin (0.06% estradiol)
- Pump delivers 0.52 mg of estradiol (100 actuations per device)
- Apply to upper arm and shoulder
- Allow to dry for 2 hours before immersing in water (e.g. swimming)
- Divigel (0.1% estradiol)
- Foil packet delivers either 0.25 mg, 0.5 mg or 1.0 mg estradiol per packet
- Apply packet contents to one upper thigh (5x7 inch area)
- Alternate to opposite side on subsequent application days
- Allow to dry for 1 hour before washing the area
- Evanmist
- References
Estraderm (C0720290) | |
|---|---|
| Concepts | Steroid (T110) , Pharmacologic Substance (T121) , Hormone (T125) |
| English | Estraderm |
| Sources | RXNORM Derived from the NIH UMLS (Unified Medical Language System) |
Estrasorb (C1320235) | |
|---|---|
| Concepts | Steroid (T110) , Pharmacologic Substance (T121) , Hormone (T125) |
| English | Estrasorb |
| Parent Concepts | Moved elsewhere (C1274021) |
| Sources | MTH, NCI, RXNORM, SCTSPA, SNOMEDCT Derived from the NIH UMLS (Unified Medical Language System) |