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Pemphigoid Gestationis

Aka: Pemphigoid Gestationis, Herpes Gestationis

Pathophysiology
1. Autoimmune skin disorder
2. Associated with HLA-DR3, and HLA-DR4
Associated conditions
1. Grave's Disease
2. Choriocarcinoma or Molar Pregnancy (rare)
Signs
1. Vesicles and bullae form on Abdomen, extremities
Management
1. Increased antepartum observation
2. Oral Antihistamines
3. Topical Corticosteroids
4. Systemic Corticosteroids in severe cases
Complications
1. Preterm delivery
2. Small for Gestational Age infant
Course
1. Onset in second-half of pregnancy
2. Improves in late pregnancy
3. May be exacerbated in early postpartum period
4. May recur in future pregnancies

Family Practice Notebook

Patients should address specific medical concerns with their physicians.

Although access to this page is not restricted, the information found here is intended for use by medical providers.

This page was written by Scott Moses, MD, last revised on 10/21/2007 and last published on 5/9/2012.

This is one of 5737 pages in the Family Practice Notebook