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Grave's DiseaseAka: Basedows Disease, Exophthalmic Goiter

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  1. See Also
    1. Thyroid Eye Disease
    2. Hyperthyroidism
  2. Epidemiology
    1. Most common cause of Thyrotoxicosis
  3. Signs: Specific to Grave's Disease
    1. See Hyperthyroidism
    2. Diffuse Goiter
    3. Audible bruit over Thyroid
    4. Infiltrative ophthalmopathy (Thyroid Eye Disease)
      1. Ophthalmoplegia
      2. Proptosis (Exophthalmos) in 50% of cases
      3. Periorbital swelling
    5. Dermopathy
      1. Pretibial Myxedema
  4. Lab
    1. Thyroid Stimulating Immunoglobulin (TSH receptor ab)
      1. Specific to Grave's Disease
      2. Linked with ophthalmopathy
      3. Usually not needed for diagnosis
      4. May be used to monitor effects of treatment
    2. Antithyroid Peroxidase Antibody negative
      1. Contrast with positive in Hashimoto's Thyroiditis
  5. Imaging
    1. Thyroid Ultrasound with doppler
      1. Thyroid hypervascularity with increased flow
    2. Thyroid uptake and scan
      1. High uptake on scan
  6. Management
    1. See Hyperthyroidism Management
    2. Referral to ophthalmology for ocular involvement

Graves' Disease (C0018213)

Definition (NCI)Hyperthyroidism associated with diffuse hyperplasia of the thyroid gland (goiter), resulting from production of antibodies that are directed against the thyrotropin receptor complex of the follicular epithelial cells. As a result, the thyroid gland enlarges and secrets increased amounts of thyroid hormones. --2004
Definition (CSP)exophthalmos occurring in association with goiter; hyperthyroidism with protrusion of the eyeballs.
Definition (MSH)A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).
ConceptsDisease or Syndrome (T047)
ICD9242.0
MSHD006111
EnglishBASEDOW DIS, BASEDOW DISEASE, Basedow's Disease, BASEDOWS DIS, Basedows Disease, DISEASE GRAVES', Exophthalmic Goiter, Exophthalmic Goiters, EXOPHTHALMIC GOITRE, FLAJANI DISEASE, GOITER EXOPHTHALMIC, Grave's disease, GRAVES DIS, GRAVES DISEASE, GRAVES' DISEASE, Graves' disease with exophthalmos, GRD, HYPERTHYROIDISM <GRAVES DISEASE>, HYPERTHYROIDISM GRAVES DISEASE, Toxic diffuse goiter with exophthalmos, Toxic diffuse goitre with exophthalmos
Spanishbocio difuso toxico con exoftalmos, enfermedad de Basedow, Enfermedad de Graves, enfermedad de Graves con exoftalmos, fenomeno de Jod - Basedow, hipertiroidismo inducido por yodo, hipertiroidismo inducido por yoduros, tirotoxicosis de Jod-Basedow, tirotoxicosis inducida por yodo
Parent ConceptsHyperthyroidism (C0020550), Autoimmune Diseases (C0004364), Goiter (C0018021), Exophthalmos (C0015300), Graves' Disease (C0018213), Thyrotoxic exophthalmos (C0155265), Autoimmune endocrine disease (C0342552), Toxic goiter (C0600086), Reason not stated concept (C1276325), Ambiguous concept (C1274012), Duplicate concept (C1274013), Antibody-mediated activation and inactivation (C1285168), Allergic disorder by body site affected (C1720649)
SourcesAOD, COSTAR, CSP, CST, DXP, LCH, MEDLINEPLUS, MSH, MTH, MTHICD9, NCI, NDFRT, OMIM, QMR, RAM, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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