Endocrinology Book

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Grave's Disease

Aka: Grave's Disease, Basedows Disease, Exophthalmic Goiter
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  1. See Also
    1. Thyroid Eye Disease
    2. Hyperthyroidism
  2. Epidemiology
    1. Most common cause of Thyrotoxicosis
  3. Signs: Specific to Grave's Disease
    1. See Hyperthyroidism
    2. Diffuse Goiter
    3. Audible bruit over Thyroid
    4. Infiltrative ophthalmopathy (Thyroid Eye Disease)
      1. Ophthalmoplegia
      2. Proptosis (Exophthalmos) in 50% of cases
      3. Periorbital swelling
    5. Dermopathy
      1. Pretibial Myxedema
  4. Lab
    1. Thyroid Stimulating Immunoglobulin (TSH receptor ab)
      1. Specific to Grave's Disease
      2. Linked with ophthalmopathy
      3. Usually not needed for diagnosis
      4. May be used to monitor effects of treatment
    2. Antithyroid Peroxidase Antibody negative
      1. Contrast with positive in Hashimoto's Thyroiditis
  5. Imaging
    1. ThyroidUltrasound with doppler
      1. Thyroid hypervascularity with increased flow
    2. Thyroid uptake and scan
      1. High uptake on scan
  6. Management
    1. See Hyperthyroidism Management
    2. Referral to ophthalmology for ocular involvement

Graves Disease (C0018213)

Definition (CHV) a condition usually caused by excessive production of thyroid hormone and characterized by an enlarged thyroid gland
Definition (CHV) a condition usually caused by excessive production of thyroid hormone and characterized by an enlarged thyroid gland
Definition (CHV) a condition usually caused by excessive production of thyroid hormone and characterized by an enlarged thyroid gland
Definition (CHV) a condition usually caused by excessive production of thyroid hormone and characterized by an enlarged thyroid gland
Definition (CHV) a condition usually caused by excessive production of thyroid hormone and characterized by an enlarged thyroid gland
Definition (CHV) a condition usually caused by excessive production of thyroid hormone and characterized by an enlarged thyroid gland
Definition (CHV) a condition usually caused by excessive production of thyroid hormone and characterized by an enlarged thyroid gland
Definition (CHV) a condition usually caused by excessive production of thyroid hormone and characterized by an enlarged thyroid gland
Definition (CHV) a condition usually caused by excessive production of thyroid hormone and characterized by an enlarged thyroid gland
Definition (NCI) Hyperthyroidism associated with diffuse hyperplasia of the thyroid gland (goiter), resulting from production of antibodies that are directed against the thyrotropin receptor complex of the follicular epithelial cells. As a result, the thyroid gland enlarges and secrets increased amounts of thyroid hormones. --2004
Definition (CSP) exophthalmos occurring in association with goiter; hyperthyroidism with protrusion of the eyeballs.
Definition (MSH) A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).
Concepts Disease or Syndrome (T047)
MSH D006111
ICD10 E05.0
SnomedCT 237823003, 367367004, 237510004, 353295004, 55807009, 190240002, 38591003, 154655004, 267464006, 367449005
English Basedow Disease, Basedow's Disease, Basedows Disease, Disease, Basedow, Exophthalmic Goiter, Exophthalmic Goiters, Goiter, Exophthalmic, Goiters, Exophthalmic, Disease, Basedow's, Disease, Graves', BASEDOW DISEASE, DISEASE GRAVES', EXOPHTHALMIC GOITER, EXOPHTHALMIC GOITRE, FLAJANI DISEASE, GOITER, EXOPHTHALMIC, GRAVES' DISEASE, GOITER EXOPHTHALMIC, HYPERTHYROIDISM <GRAVES DISEASE>, HYPERTHYROIDISM, AUTOIMMUNE, GRD, GRAVES DISEASE, BASEDOW DIS, BASEDOWS DIS, GRAVES DIS, Graves' disease (diagnosis), Grave's disease, Graves' disease (diffuse toxic goiter), grave's disease, Autoimmune hyperthyroidism, Disease Graves', Goiter exophthalmic, GRAVE DISEASE, HYPERTHYROIDISM GRAVES DISEASE, Graves Disease, Basedow disease, Graves Disease [Disease/Finding], Disease;Basedows, basedows disease, hyperthyroidism graves disease, Disease;Graves, disease graves, basedow's disease, graves' disease, graves disease, basedow disease, diseases graves, Basedow's disease, Graves' disease, Graves' disease with exophthalmos, Toxic diffuse goiter with exophthalmos, Exophthalmic goiter, Exophthalmic goitre, Toxic diffuse goitre with exophthalmos, Graves' disease (disorder), Toxic diffuse goiter with exophthalmos (disorder), Basedow's disease (disorder), Flajani, Graves, Basedow, exophthalmic; goiter, exophthalmos; goiter (etiology), exophthalmos; goiter (manifestation), goiter; exophthalmos (etiology), goiter; exophthalmos (manifestation), struma; exophthalmic, Graves' disease [Ambiguous], exophthalmic goiter, Graves' Disease, Disease, Graves, Graves disease, Basedows disease, Graves-Basedow disease
French GOITRE EXOPHTALMIQUE, MALADIE DE GRAVES-BASEDOW, Hyperthyroïdie autoimmune, Goitre exophtalmique, Maladie de Basedow, Goitre toxique diffus, Maladie de Graves-Basedow, Maladie de Graves
Spanish ENFERMEDAD DE GRAVES, BOCIO EXOFTALMICO, Bocio exoftálmico, Enfermedad de Graves-Basedow, Graves disease, Graves' disease [Ambiguous], Graves' disease, Basedow's disease, Hipertiroidismo autoinmune, Enfermedad de Graves, Enfermedad de Graves (trastorno), bocio difuso tóxico con exoftalmos, enfermedad de Basedow (trastorno), enfermedad de Basedow, enfermedad de Graves (concepto no activo), enfermedad de Graves (trastorno), enfermedad de Graves con exoftalmos (trastorno), enfermedad de Graves con exoftalmos, enfermedad de Graves, Enfermedad de Basedow, Bocio Exoftálmico, Bocio Exoftalmico
Portuguese BOCIO EXOFTALMICO, Doença de Graves-Basedow, Bócio exoftálmico, DOENCA DE GRAVES-BASEDOW, Hipertiroidismo autoimune, Bócio Exoftalmico, Doença de Basedow, Doença de Graves
Dutch ziekte van Graves-Basedow, struma exoftalmisch, exoftalmische struma, exoftalmisch struma, ziekte van Graves, auto-immune hyperthyreoïdie, exoftalmie; struma, struma; exoftalmie, ziekte van Basedow, Basedow, ziekte van, Exoftalmisch struma, Struma, exoftalmisch, Ziekte van Graves
German Krankheit Basedow, Krankheit Graves, Graves-Basedow Krankheit, autoimmune Schilddruesenueberfunktion, BASEDOWSCHE KRANKHEIT, MORBUS BASEDOW, Basedow-Krankheit, Basedow-Struma, Exophthalmus mit Struma, Graves-Krankheit
Italian Malattia di Graves-Basedow, Malattia di Graves, Ipertiroidismo autoimmunitario, Gozzo esoftalmico, Morbo di Basedow, Morbo di Basedow-Graves, Malattia di Flajani-Basedow-Graves, Morbo di Graves
Japanese グレーブス・バセドウ病, ﾊﾞｾﾄﾞｳﾋﾞｮｳ, ｸﾞﾚｰﾌﾞｽﾋﾞｮｳ, ｸﾞﾚｰﾌﾞｽﾊﾞｾﾄﾞｳﾋﾞｮｳ, ｼﾞｺﾒﾝｴｷｾｲｺｳｼﾞｮｳｾﾝｷﾉｳｺｳｼﾝｼｮｳ, 自己免疫性甲状腺機能亢進症, ｶﾞﾝｷｭｳﾄｯｼｭﾂｾｲｺｳｼﾞｮｳｾﾝｼｭ, Graves氏病, グレーヴス病, グレーヴズ病, バセドウ病, 眼球突出性甲状腺腫, グレーブス病, 浸潤性眼障害, バーゼドー病, バセドー病, 眼障害-浸潤性, 甲状腺腫-眼球突出性, Basedow病, Graves病
Swedish Giftstruma
Czech Gravesova nemoc, Basedowova nemoc, Exoftalmická struma, Autoimunní hypertyroidismus, Basedowova choroba, Gravesova choroba, Graves-Basedowova choroba
Finnish Basedowin tauti
Russian BAZEDOVA BOLEZN', EKZOFTAL'MICHESKII ZOB, GREIVSA BOLEZN', ZOB EKZOFTAL'MICHESKII, ZOB DIFFUZNYI TOKSICHESKII, БАЗЕДОВА БОЛЕЗНЬ, ГРЕЙВСА БОЛЕЗНЬ, ЗОБ ДИФФУЗНЫЙ ТОКСИЧЕСКИЙ, ЗОБ ЭКЗОФТАЛЬМИЧЕСКИЙ, ЭКЗОФТАЛЬМИЧЕСКИЙ ЗОБ
Croatian GRAVESOVA BOLEST
Polish Choroba Gravesa-Basedowa, Wole nadczynne
Hungarian Graves-kór, Autoimmun hyperthyreosis, Graves betegség, Graves-Basedow-kór, Basedow-kór, Exophthalmikus struma
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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