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Benzodiazepine AbuseAka: Benzodiazepine Dependence, Tranquilizer, Benzodiazepine Withdrawal

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  1. See Also
    1. Chemical Dependency
    2. Substance Abuse Evaluation
  2. Class
    1. Sedative-relaxant
  3. Medical Uses
    1. See Benzodiazepines
  4. Toxicity
    1. Respiratory Depression
    2. Coma
    3. Hypotension
    4. Rarely lethal alone, but dangerous with Alcohol
  5. Toxicity Management
    1. Flumazenil (Romazicon)
  6. Taper Schedules
    1. Calculate Valium to Benzodiazepine Equivalents
      1. Start at 50% of calculated Valium dose
    2. Example
      1. Xanax 6 mg is equivalent to 60 mg Diazepam
      2. Xanax 10 mg is equivalent to 100 mg Diazepam
      3. Start taper at 50% or 50 mg Valium per day
      4. Decrease dosing per Valium taper below
    3. Valium Protocol
      1. Days 1-3: 10 mg tid (30 mg/day)
      2. Days 4-6: 5 mg qid (20 mg/day)
      3. Days 7-9: 5 mg tid (15 mg/day)
      4. Days 10-12: 5 mg bid (10 mg/day)
      5. Days 13-15: 5 mg qd (5 mg/day)

Tranquilizing Agents (C0040614)

Definition (MSH)A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes.
Definition (CSP)drug with a calming, soothing effect.
ConceptsPharmacologic Substance (T121)
MSHD014149
EnglishAtaractics, tranquilizer, Tranquilizer agent, Tranquilizer drug, Tranquilizers, Tranquilizing Agents, Tranquilizing Drugs, Tranquilliser, Tranquilliser agent, Tranquilliser drug, Tranquillizing Agents, Tranquillizing Drugs
Spanishansiolitico, farmaco ansiolitico, farmaco sedante, tranquilizante
Parent ConceptsCentral Nervous System Depressants (C0007681), psychopharmacologic agent (C0597318), Psychotropic Drugs (C0033978), Sedative/neuroleptic (C0360112)
SourcesAOD, CSP, LCH, LNC, MSH, MTH, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Benzodiazepine dependence (C0338768)

ConceptsMental or Behavioral Dysfunction (T048)
EnglishBenzodiazepine dependence
Spanishdependencia de benzodiazepinas
Parent ConceptsSedative dependence (C0270380), Duplicate concept (C1274013)
SourcesSCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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