III. Dosing

  1. Parenteral
    1. Initial: 1 mg SC/IM/IV over 3-4 minutes
    2. Repeat: May repeat every 1 hour
    3. Maximum: 3 mg/day, 6 mg/week, 20 mg/month
  2. Intranasal Dihydroergotamine (Migranal)

IV. Advantages

  1. Weaker Vasoconstrictor (less Side Effects)
  2. No Rebound Headache

V. Adverse Effects

  1. Retroperitoneal fibrosis

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Cost: Medications

dihydroergotamine (on 4/19/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
DIHYDROERGOTAMINE 1 MG/ML AM Generic $113.59 per ml
DIHYDROERGOTAMINE MESYLATE 4 MG/ML NASAL SPRAY Generic $375.81 per ml

Ontology: Dihydroergotamine (C0012291)

Definition (MSH) A 9,10alpha-dihydro derivative of ERGOTAMINE. It is used as a vasoconstrictor, specifically for the therapy of MIGRAINE DISORDERS.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D004087
SnomedCT 363557006, 387267005, 48875009
English Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha,10alpha)-, 9,10-Dihydroergotamine, Dihydroergotamine [Chemical/Ingredient], Dihydroergotamine product (product), dihydroergotamine, DIHYDROERGOTAMINE, Dihydroergotamine (substance), Dihydroergotamine (product), Dihydroergotamine product, Dihydroergotamine product (substance), Dihydroergotamine
Swedish Dihydroergotamin
Czech dihydroergotamin
Finnish Dihydroergotamiini
Russian DIGIDROERGOTAMIN, ДИГИДРОЭРГОТАМИН
Japanese ヒポラール, ジヒドロエルゴタミンメシル酸塩, メシル酸ジヒドロエルゴタミン, ハイデルゴット, ジヒドロエルゴタミン, ジヒデルゴット
Croatian DIHIDROERGOTAMIN
Polish Dihydroergotamina, Dwuhydroergotamina
Portuguese Di-Hidroergotamina
Spanish dihidroergotamina, producto (producto), dihidroergotamina, producto, dihidroergotamina (sustancia), dihidroergotamina, dihidroergotamina (producto), Dihidroergotamina
French Dihydroergotamine
German Dihydroergotamin
Italian Diidroergotammina