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MethysergideAka: Sansert

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  1. Indications
    1. Second line drug for Migraine Prophylaxis
    2. Use only with Neurology consultation (due to toxicity)
  2. Mechanism
    1. Serotonin Antagonist (partial agonist activity)
  3. Dosing
    1. Sansert 4-8 mg PO qd
    2. Drug holiday for 4 weeks every 6 months
  4. Adverse Effects
    1. Retroperitoneal fibrosis
    2. Weight gain
    3. Edema

Methysergide (C0025842)

Definition (MSH)An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishDimethylergometrin, Methylmethylergonovine, methylsergide, Methysergide, METHYSERGIDE PREPARATION, Methysergide product
Spanishmetisergida
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Sansert (C0036177)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishAlliance Brand of Methysergide Maleate, Désernil Sandoz, Deseril, Desril, Novartis Brand of Methysergide Maleate, Sansert
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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