http://www.fpnotebook.com/
ErgotamineAka: Wigraine
- Indications
- Migraine Abortive Management
- Dosing
- Sublingual
- One tab SL
- Repeat in 1/2 hour prn
- Maximum: 3/day or 6/week
- Oral tablets available
- Rectal Suppository (Wigraine)
- One rectally at Headache onset
- May repeat hourly
- Maximum: 2 suppositories per day or 12 per month
- Limit no more than 2 days per week
- May use for Menstrual Migraine
- Adverse Effects
- Nausea, Vomiting
- Use Antiemetic
- Rebound Headache
- Occluded vessel in overdose
- Overdose levels
- Daily use exceeds 6 mg
- Weekly use exceeds 10 mg
- Potentiated by
- Beta Blockers
- Dopamine
- Fever
- Liver Disease
|
|---|
| Definition (MSH) | A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of MIGRAINE DISORDERS. |
| Definition (NCI) | A naturally occurring ergot alkaloid with vasoconstrictor and analgesic property. Ergotamine selectively binds and activates serotonin (5-HT) 1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, thereby resulting in vasoconstriction and reducing the blood flow in cerebral arteries that may lead to relieve of vascular headaches. This agent also selectively binds to alpha-adrenergic receptors, thereby stimulating vascular smooth muscle and causing vasoconstriction in both arteries and veins, which also contributes to the relief of headaches. Furthermore, the activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. |
| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
|
| English | Ergotamine, ERGOTAMINE PREPARATION, Ergotamine product |
| Spanish | ergotamina |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
|
Navigation Tree
