II. Dosing

  1. Adult: 1.5-2.5 grams PO qd
  2. Pediatric: 15-30 mg/kg/day (Max 2g/day)

III. Adverse Effects

  1. Hepatotoxicity
  2. Arthralgias
  3. Gastrointestinal upset
  4. Rash
  5. Hyperuricemia

IV. Monitoring

  1. Baseline
    1. Liver Function Tests
    2. Serum Creatinine
  2. Periodic testing
    1. Liver Function Tests repeated 1-2 times monthly if risks for hepatotoxicity
    2. Serum Uric Acid if symptoms related to gout

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Cost: Medications

pyrazinamide (on 11/30/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
PYRAZINAMIDE 500 MG TABLET Generic $2.59 each

Ontology: Pyrazinamide (C0034239)

Definition (NCI) A synthetic pyrazinoic acid amide derivative with bactericidal property. Pyrazinamide is particularly active against slowly multiplying intracellular bacilli (unaffected by other drugs) by an unknown mechanism of action. Its bactericidal action is dependent upon the presence of bacterial pyrazinamidase, which removes the amide group to produce active pyrazinoic acid. Pyrazinamide is an important component of multidrug therapy for tuberculosis. (NCI04)
Definition (MSH) A pyrazine that is used therapeutically as an antitubercular agent.
Definition (CSP) antibacterial derived from nicotinic acid, used as a tuberculostatic.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D011718
SnomedCT 13592004, 387076005
LNC LP15007-5, MTHU001493
English Pyrazinamide, Pyrazinecarboxamide, pyrazinamide, pyrazinamide (medication), Pyrazinamide [Chemical/Ingredient], PYRAZINAMIDE, Pyrazinoic acid amide, Pyrazinamide (product), Pyrazinamide (substance)
Swedish Pyrazinamid
Czech pyrazinamid
Finnish Pyratsiiniamidi
Russian PIRAZINAMID, ПИРАЗИНАМИД
Japanese ピラジナミド
Spanish Pirazinamida, Piracinamida, amida de ácido pirazinoico, pirazinamida (producto), pirazinamida (sustancia), pirazinamida
Polish Pirazynamid
French Pyrazinamide
German Pyrazinamid
Italian Pirazinamide
Portuguese Pirazinamida