III. Preparations: Oral agents

  1. Cefixime (Suprax)
    1. Adult
      1. Standard: 400 mg PO divided qd to bid
      2. Gonorrhea: 400 mg PO for single dose
    2. Child: 8 mg/kg/day divided qd to bid
  2. Cefpodoxime (Vantin)
    1. Good activity Gram Positive organisms
      1. Covers Staphylococcus aureus
      2. Covers Pneumococcus
    2. Adult: 100 to 400 mg PO bid
    3. Child
      1. Pharyngitis: 10 mg/kg/day divided bid
      2. Otitis Media: 10 mg/kg/day divided qd

IV. Preparations: Parenteral agents

  1. Cefotaxime (Claforan)
    1. Most Staphylococcus aureus and Anaerobic activity
    2. Adult: 1 to 2 grams IM or IV every 6 to 8 hours
    3. Child
      1. Standard: 50-150 mg/kg/day IM or IV divided q4-6h
      2. Meningitis: 200 mg/kg/day IV divided q6-8h
      3. Maximum dose: 2 grams
  2. Ceftizoxime (Cefizox)
    1. Moderate Staphylococcus aureus and Anaerobic Activity
    2. Adult: 1 to 2 grams IV every 8 to 12 hours
    3. Child: 50 mg/kg/dose IV every 6 to 8 hours
  3. Ceftriaxone (Rocephin)
    1. Least Staphylococcus and Anaerobic activity
    2. Dilute in Lidocaine 1% for Intramuscular Injection
    3. Adult
      1. Standard: 1-2 grams IM or IV every 24 hours
      2. Gonorrhea: 250 mg IM single dose
    4. Child
      1. Standard: 50-75 mg/kg/day IV divide q12-24 hours
      2. Meningitis: 100 mg/kg/day IV divided q12-24 hours
      3. Otitis Media: 50 mg/kg IM single dose (max: 1g)
      4. Maximum Dose: 2 grams (4 grams for Meningitis)

Images: Related links to external sites (from Google)

Cost: Medications

CefTRIAXone Sodium (on 2/9/2012 at DrugStore.com)
CefTRIAXone Sodium 1gm Solution Vial #1 for $26.99 ($26.99/unit)
CefTRIAXone Sodium 2gm Solution Vial #1 for $49.99 ($49.99/unit)
Cefpodoxime Proxetil (on 2/9/2012 at DrugStore.com)
Cefpodoxime Proxetil 200mg Tablets #20 for $127.00 ($6.35/unit)
Rocephin (on 2/9/2012 at DrugStore.com)
Rocephin 1gm Solution Vial #1 for $70.99 ($70.99/unit)
Vantin (on 2/9/2012 at DrugStore.com)
Vantin 100mg/5ml Suspension 100ml Bottle #1 for $113.99 ($113.99/unit)
Vantin 20 100mg Tablets Bottle #1 for $127.99 ($127.99/unit)
Vantin 20 200mg Tablets Bottle #1 for $194.37 ($194.37/unit)

Ontology: Cefotaxime (C0007554)

Definition (MSH) Semisynthetic broad-spectrum cephalosporin.
Definition (PDQ) A third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39177&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39177&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C354" NCI Thesaurus)
Definition (NCI) A third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis.
Concepts Organic Chemical (T109) , Antibiotic(T195)
MSH D002439
SnomedCT 3334000, 372704003
English Cefotaxim, Cefotaxime, Cephotaxim, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-, monosodium salt, (6R-(6alpha,7beta(Z)))-, cefotaxime, cefotaxime (medication), Cefotaxime [Chemical/Ingredient], cefotaxim, Cefotaxime product, Cefotaxime (product), Cefotaxime (substance), CEFOTAXIME
Swedish Cefotaxim
Czech cefotaxim
Finnish Kefotaksiimi
Russian TSEFOTAKSIM, ЦЕФОТАКСИМ
Japanese セフォタキシム
Croatian CEFOTAKSIM
Polish Cefotaksym
Spanish cefotaxima (producto), cefotaxima (sustancia), cefotaxima, Cefotaxima
French Céfotaxime
German Cefotaxim
Italian Cefotaxima
Portuguese Cefotaxima

Ontology: Ceftizoxime (C0007560)

Definition (NCI) A semisynthetic, broad-spectrum, beta-lactamase-resistant, third-generation cephalosporin with antibacterial activity. Ceftizoxime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Definition (MSH) A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
Concepts Organic Chemical (T109) , Antibiotic(T195)
MSH D015296
SnomedCT 372770006, 54577009
English Ceftizoxime, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-, (6R-(6alpha,7beta(Z)))-, ceftizoxime, Ceftizoxime [Chemical/Ingredient], Ceftizoxime (product), Ceftizoxime (substance), CEFTIZOXIME
Swedish Ceftizoxim
Czech ceftizoxim, cefpodoxim proxetil
Finnish Keftitsoksiimi
Russian TSEFTIZOKSIM, ЦЕФТИЗОКСИМ
Japanese セフチゾキシムナトリウム, セフチゾキシム
Croatian CEFTIZOKSIM
Polish Ceftyzoksym
Spanish ceftizoxima (producto), ceftizoxima (sustancia), ceftizoxima, Ceftizoxima
French Ceftizoxime
German Ceftizoxim
Italian Ceftizoxima
Portuguese Ceftizoxima

Ontology: Rocephin (C0035750)

Concepts Organic Chemical (T109) , Antibiotic(T195)
MSH D002443
English Rocefin, ceftriaxone (Rocephin), rocefin, rocephin, Rocephin, Hoffman La Roche Brand of Ceftriaxone Sodium, Hoffman-La Roche Brand of Ceftriaxone Sodium, Rocefalin, Rocephine, Roche Brand of Ceftriaxone Sodium

Ontology: cefpodoxime (C0055011)

Definition (NCI) A third generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefpodoxime's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefpodoxime inhibits bacterial septum and cell wall synthesis formation.
Concepts Organic Chemical (T109) , Antibiotic(T195)
MSH C053268
SnomedCT 387534007, 96049003
English 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(methoxymethyl)-8-oxo-, monosodium salt, (6R-(6alpha,7beta(Z)))-, cefpodoxime, CEFPODOXIME, Cefpodoxime, Cefpodoxime (product), Cefpodoxime (substance)
Spanish cefpodoxima (producto), cefpodoxima (sustancia), cefpodoxima

Ontology: Cefixime (C0060400)

Definition (NCI) An antibiotic drug used to treat infection. It belongs to the family of drugs called cephalosporins.
Definition (MSH) A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.
Definition (NCI) A broad-spectrum, third-generation cephalosporin antibiotic derived semisynthetically from the marine fungus Cephalosporium acremonium with antibacterial activity. As does penicillin, the beta-lactam antibiotic cefixime inhibits bacterial cell wall synthesis by disrupting peptidoglycan synthesis, resulting in a reduction in bacterial cell wall stability and bacterial cell lysis. Stable in the presence of a variety of beta-lactamases, this agent is more active against gram-negative bacteria and less active against gram-positive bacteria compared to second-generation cephalosporins.
Definition (PDQ) A broad-spectrum, third-generation cephalosporin antibiotic derived semisynthetically from the marine fungus Cephalosporium acremonium with antibacterial activity. As does penicillin, the beta-lactam antibiotic cefixime inhibits bacterial cell wall synthesis by disrupting peptidoglycan synthesis, resulting in a reduction in bacterial cell wall stability and bacterial cell lysis. Stable in the presence of a variety of beta-lactamases, this agent is more active against gram-negative bacteria and less active against gram-positive bacteria compared to second-generation cephalosporins. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=37809&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=37809&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1100" NCI Thesaurus)
Concepts Organic Chemical (T109) , Antibiotic(T195)
MSH D020682
SnomedCT 387536009, 96052006
English cefixime, cefixime (medication), 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-(((2-amino-4-thiazolyl)((carboxymethoxy)imino)acetyl)amino)3-ethenyl-8-oxo-, trihydrate, (6R-(6alpha,7beta(Z)))-, Cefixime [Chemical/Ingredient], Cefixime (product), Cefixime (substance), CEFIXIME, Cefixime
Swedish Cefixim
Czech cefixim
Finnish Kefiksiimi
Russian TSEFIKSIM, ЦЕФИКСИМ
Japanese セフィキシム
Polish Cefiksym
Spanish cefixima (producto), cefixima (sustancia), cefixima, Cefixima
French Céfixime
German Cefixim
Italian Cefixima
Portuguese Cefixima

Ontology: Claforan (C0701052)

Concepts Organic Chemical (T109) , Antibiotic(T195)
MSH D002439
English Claforan ADD-Vantage, claforan, Claforan, Klaforan, Aventis Brand of Cefotaxime Sodium, Aventis Pharma Brand of Cefotaxime Sodium, Hoechst Brand of Cefotaxime Sodium, Primafen

Ontology: Vantin (C0724204)

Concepts Organic Chemical (T109) , Antibiotic(T195)
MSH C053267
English Vantin, vantin