Infectious Disease Book

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Second Generation Broad-spectrum CephalosporinsAka: Second Generation Cephalosporins, Cefuroxime, Loracarbef, Cefprozil, Lorabid, Cefzil, Ceftin

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  1. See Also
    1. Second Generation Anti-anaerobe Cephalosporins
  2. Coverage
    1. Gram Positive Cocci
    2. EKP Gram Negative Bacteria
    3. Gram Negative Coccobacilli
  3. Indications
    1. Respiratory tract infections
    2. Acute Sinusitis
    3. Otitis Media
  4. Preparations
    1. Loracarbef (Lorabid)
      1. Adult: 200 to 400 mg po bid
      2. Child
        1. Otitis Media: 30 mg/kg/day divided bid
        2. Other infections: 15 mg/kg/day divided bid
      3. Directions
        1. Take more than 1 hour before or 2 hours after food
    2. Cefprozil (Cefzil)
      1. Adult: 250 to 500 mg PO divided qd to bid
      2. Child
        1. Otitis Media: 15 mg/kg/dose PO bid
        2. Pharyngitis: 7.5 mg/kg/dose PO bid for 10 days
    3. Cefuroxime (Ceftin, Zinacef)
      1. Adult
        1. Parenteral: 750 to 1500 mg IM or IV every 8 hours
        2. Oral: 250 to 500 mg PO bid
      2. Child
        1. Parenteral: 50-100 mg/kg/day IV divided q6-8 hours
        2. Oral: 20-30 mg/kg/day PO divided bid
          1. Reported to have unpleasant taste
      3. Directions
        1. Take with food
    4. Cefaclor (Ceclor)
      1. Listed for historical reference only
      2. Risk of significant serum-sickness type reaction

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