Infectious Disease Book

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Second Generation Anti-anaerobe CephalosporinsAka: Cefoxitin, Cefotetan, Cefamandole

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  1. See Also
    1. Second Generation Broad-spectrum Cephalosporins
  2. Coverage
    1. Bacteroides
  3. Indications
    1. Abdominal Surgery prophylaxis
    2. Colorectal surgery prophylaxis
  4. Coverage
    1. Cefoxitin (Mefoxin) 1-2 grams IM or IV every 6-8 hours
    2. Cefotetan (Cefotan) 1-2 grams IM or IV every 12 hours
    3. Cefamandole
  5. Downsides
    1. Poor overall activity
    2. Expensive

Cefamandole (C0007541)

Definition (MSH)Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate.
ConceptsOrganic Chemical (T109) , Antibiotic (T195)
EnglishCefamandole, CEFAMANDOLE PREPARATION, Cephamandole
Spanishcefamandol
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Cefotetan (C0007555)

Definition (MSH)A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.
Definition (NCI)A semi-synthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin antibiotic derived from cephalosporium. The bactericidal activity of cefotetan disodium is caused by an inhibition of bacterial cell wall synthesis via inhibition of cross-linking of peptidoglycans. This results in a reduction of cell wall stability and causes cell lysis. Cefotetan disodium is more active against gram-negative organisms and less active against gram-positive organisms compared to first-generation cephalosporins.
ConceptsOrganic Chemical (T109) , Antibiotic (T195)
EnglishCefotetan, CEFOTETAN PREPARATION, Cefotetan product
Spanishcefotetán, cefotetan, producto con cefotetán, producto con cefotetan
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Cefoxitin (C0007557)

Definition (MSH)A semisynthetic cephamycin antibiotic resistant to beta-lactamase.
ConceptsOrganic Chemical (T109) , Antibiotic (T195)
EnglishCefoxitin, CEFOXITIN PREPARATION
Spanishcefoxitina
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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