Infectious Disease Book

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Third Generation Anti-Pseudomonal CephalosporinsAka: Ceftazidime

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  1. See Also
    1. Third Generation Broad-Spectrum Cephalosporins
  2. Coverage
    1. Pseudomonas (Main indication)
    2. EKP Gram Negative Bacteria
    3. ESP Gram Negative Bacteria
    4. Gram Positive Cocci poorly covered
    5. No Gram Negative Coccobacilli coverage
  3. Preparations: Ceftazidime (Fortaz)
    1. Adult: 1-2 grams IM or IV every 8 to 12 hours
    2. Child: 30-50 mg/kg IV every 8 hours
  4. Disadvantages
    1. Most expensive
    2. Limited spectrum

Ceftazidime (C0007559)

Definition (MSH)Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.
Definition (NCI)A beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftazidime binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftazidime is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftazidine also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS).
ConceptsOrganic Chemical (T109) , Antibiotic (T195)
EnglishCeftazidime, CEFTAZIDIME PREPARATION
Spanishceftazidima
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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