Ophthalmology Book

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Intraocular Carbonic Anhydrase Inhibitor

Aka: Intraocular Carbonic Anhydrase Inhibitor, Dorzolamide, Trusopt, Brinzolamide, Azopt
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  1. Indication
    1. Open Angle Glaucoma
    2. Patients unable to tolerate Beta Blocker or as adjunct
  2. Mechanism
    1. Inhibits bicarbonate formation in the ciliary body
    2. Results in decreased aqueous production
  3. Preparations
    1. Topical
      1. Dorzolamide (Trusopt) 2%, 1 drop tid
      2. Brinzolamide (Azopt) 1%, 1 drop tid
    2. Systemic
      1. Acetazolamide (Diamox)
      2. Methazolamide (Neptazane)
  4. Adverse Effects
    1. Topical is well tolerated (contrast with oral)
    2. Systemic
      1. Paresthesias in hands and face
      2. Malaise, anorexia, and severe weight loss
      3. Hypokalemia
      4. Nephrolithiasis
  5. Reference
    1. (1995) Med Lett Drugs Ther 37:(956):76-77
Medication Costs
Dorzolamide HCl (on 2/9/2012 at DrugStore.com)
Dorzolamide HCl 2% Solution 10ml Bottle #1 for $61.99 ($61.99/unit)
Dorzolamide-Timolol (on 2/9/2012 at DrugStore.com)
Dorzolamide-Timolol 2-0.5% Solution 10ml Bottle #1 for $99.99 ($99.99/unit)
Trusopt (on 2/9/2012 at DrugStore.com)
Trusopt 2% Solution 10ml #1 for $79.25 ($79.25/unit)
Azopt (on 2/9/2012 at DrugStore.com)
Azopt 1% Suspension 10ml Bottle #1 for $127.19 ($127.19/unit)
Azopt 1% Suspension 15ml Bottle #1 for $172.99 ($172.99/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

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