II. Indications

III. Mechanism

  1. Decrease Aqueous Humor production and increases outflow (lowers IOP 20 to 25%)

IV. Medications (purple cap)

  1. Apraclonidine (Lopidine)
  2. Brimonidine (Alphagan)
    1. Available as combination with Brinzolamide (Simbrinza)
    2. Mirvaso (Brimonidine gel)
      1. Indicated for Eye Redness due to Rosacea
    3. Lumify (OTC Brimonidine 0.025%) released in 2018
      1. Marketed as OTC to reduce Eye Redness
      2. No proof that it is more effective than OTC ocular Decongestants (e.g. visine) and more expensive
      3. Evaluate Eye Redness for underlying cause instead
      4. (2018) presc lett 25(6): 35 [PubMed]

V. Drug Interactions

VI. Adverse Effects

  1. Eye itching, burning or stinging
  2. Dry Mouth

VII. Efficacy

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Related Studies

Cost: Medications

apraclonidine (on 9/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
APRACLONIDINE HCL 0.5% DROPS Generic $11.32 per ml
brimonidine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
BRIMONIDINE 0.2% EYE DROP Generic $0.74 per ml
BRIMONIDINE 0.33% GEL PUMP Generic $14.63 per gram
BRIMONIDINE TARTRATE 0.1% DROP Generic $30.21 per ml
BRIMONIDINE TARTRATE 0.15% DRP Generic $23.45 per ml
BRIMONIDINE-TIMOLOL 0.2%-0.5% Generic $27.65 per ml
alphagan (on 1/14/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
ALPHAGAN P 0.1% DROPS $35.54 per ml
ALPHAGAN P 0.15% EYE DROPS Generic $23.45 per ml
lumify (on 3/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
LUMIFY 0.025% EYE DROP OTC $2.99 per ml