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Intraocular ProstaglandinAka: Latanoprost, Xalatan, Bimatoprost, Lumigan, Travoprost, Travatan, Unoprostone, Rescula

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  1. Indication
    1. First line agent for Open Angle Glaucoma
  2. Mechanism
    1. Prostaglandin analogs that increase aqueous outflow
  3. Agents
    1. Latanoprost (Xalatan) 0.005% one drop qd
    2. Bimatoprost (Lumigan) 0.030% one drop qd
    3. Travoprost (Travatan) 0.004% one drop qd
    4. Unoprostone (Rescula) 0.150% one drop bid
  4. Efficacy: Latanoprost
    1. Highly effective, low side effect agent
    2. Currently most prescribed Glaucoma agent worldwide
    3. References
      1. Hedman (2000) Eur J Ophthalmol 10:95
  5. Adverse Effects
    1. Increased eyelash growth or pigmentation
    2. Altered iris pigmentation

latanoprost (C0090306)

Definition (NCI)A prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
Englishlatanaprost, latanoprost, LATANOPROST PREPARATION
Spanishlatanoprost
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Xalatan (C0593887)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishPharmacia Brand of Latanoprost, Xalatan
CreditsDerived from the NIH UMLS (Unified Medical Language System)


UNOPROSTONE (C0772319)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishUNOPROSTONE, UNOPROSTONE PREPARATION
CreditsDerived from the NIH UMLS (Unified Medical Language System)


travoprost (C0937916)

Definition (NCI)A synthetic lipophilic isopropyl ester prodrug of the active compound travoprost free acid, a prostaglandin F2alpha analog with anti-glaucoma property. Upon administration, travoprost is hydrolysed to a free acid by corneal esterases, and then selectively stimulating the prostaglandin F (FP prostanoid) receptor, thereby increasing the uveoscleral outflow which leads to a reduction in intra-ocular pressure.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
Englishtravoprost, TRAVOPROST @ @ UNIDENTIFIED, TRAVOPROST PREPARATION, TRAVOPROST UNIDENTIFIED
Spanishtravoprost
CreditsDerived from the NIH UMLS (Unified Medical Language System)


bimatoprost (C0937917)

Definition (NCI)A synthetic prostamide and structural prostaglandin analogue with ocular hypotensive activity. Bimatoprost mimics the effects of the endogenous prostamides and reduces intracocular pressure by increasing outflow of aqueous humor through both the pressure-sensitive outflow pathway (the trabecular meshwork), and the pressure-insensitive outflow pathway (the uveoscleral routes). It is not clear whether bimatoprost lowers intraocular pressure by stimulating F-Prostanoid receptors or by acting on specific prostamide receptors.
ConceptsLipid (T119) , Pharmacologic Substance (T121)
Englishbimatoprost, BIMATOPROST @ @ UNIDENTIFIED, BIMATOPROST PREPARATION, BIMATOPROST UNIDENTIFIED
Spanishbimatoprost
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Lumigan (C0939372)

ConceptsLipid (T119) , Pharmacologic Substance (T121)
EnglishAllergan brand of bimatoprost, Lumigan
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Eescula (C0939466)

ConceptsEicosanoid (T111) , Pharmacologic Substance (T121)
EnglishCiba Vision brand of isopropyl unoprostone, Eescula, Novartis brand of isopropyl unoprostone, Rescula
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Travatan (C0939506)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishAlcon brand of travoprost, Travatan
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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