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Intraocular ProstaglandinAka: Latanoprost, Xalatan, Bimatoprost, Lumigan, Travoprost, Travatan, Unoprostone, Rescula
- Indication
- First line agent for Open Angle Glaucoma
- Mechanism
- Prostaglandin analogs that increase aqueous outflow
- Agents
- Latanoprost (Xalatan) 0.005% one drop qd
- Bimatoprost (Lumigan) 0.030% one drop qd
- Travoprost (Travatan) 0.004% one drop qd
- Unoprostone (Rescula) 0.150% one drop bid
- Efficacy: Latanoprost
- Highly effective, low side effect agent
- Currently most prescribed Glaucoma agent worldwide
- References
- Hedman (2000) Eur J Ophthalmol 10:95
- Adverse Effects
- Increased eyelash growth or pigmentation
- Altered iris pigmentation
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| Definition (NCI) | A prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure. |
| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | latanaprost, latanoprost, LATANOPROST PREPARATION |
| Spanish | latanoprost |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | Pharmacia Brand of Latanoprost, Xalatan |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | UNOPROSTONE, UNOPROSTONE PREPARATION |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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| Definition (NCI) | A synthetic lipophilic isopropyl ester prodrug of the active compound travoprost free acid, a prostaglandin F2alpha analog with anti-glaucoma property. Upon administration, travoprost is hydrolysed to a free acid by corneal esterases, and then selectively stimulating the prostaglandin F (FP prostanoid) receptor, thereby increasing the uveoscleral outflow which leads to a reduction in intra-ocular pressure. |
| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
|
| English | travoprost, TRAVOPROST @ @ UNIDENTIFIED, TRAVOPROST PREPARATION, TRAVOPROST UNIDENTIFIED |
| Spanish | travoprost |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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| Definition (NCI) | A synthetic prostamide and structural prostaglandin analogue with ocular hypotensive activity. Bimatoprost mimics the effects of the endogenous prostamides and reduces intracocular pressure by increasing outflow of aqueous humor through both the pressure-sensitive outflow pathway (the trabecular meshwork), and the pressure-insensitive outflow pathway (the uveoscleral routes). It is not clear whether bimatoprost lowers intraocular pressure by stimulating F-Prostanoid receptors or by acting on specific prostamide receptors. |
| Concepts | Lipid (T119)
, Pharmacologic Substance (T121)
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| English | bimatoprost, BIMATOPROST @ @ UNIDENTIFIED, BIMATOPROST PREPARATION, BIMATOPROST UNIDENTIFIED |
| Spanish | bimatoprost |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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| Concepts | Lipid (T119)
, Pharmacologic Substance (T121)
|
| English | Allergan brand of bimatoprost, Lumigan |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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| Concepts | Eicosanoid (T111)
, Pharmacologic Substance (T121)
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| English | Ciba Vision brand of isopropyl unoprostone, Eescula, Novartis brand of isopropyl unoprostone, Rescula |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | Alcon brand of travoprost, Travatan |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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