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Intraocular ProstaglandinAka: Latanoprost, Xalatan, Bimatoprost, Lumigan, Travoprost, Travatan, Unoprostone, Rescula

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  1. Indication
    1. First line agent for Open Angle Glaucoma
  2. Mechanism
    1. Prostaglandin analogs that increase aqueous outflow
  3. Agents
    1. Latanoprost (Xalatan) 0.005% one drop qd
    2. Bimatoprost (Lumigan) 0.030% one drop qd
    3. Travoprost (Travatan) 0.004% one drop qd
    4. Unoprostone (Rescula) 0.150% one drop bid
  4. Efficacy: Latanoprost
    1. Highly effective, low side effect agent
    2. Currently most prescribed Glaucoma agent worldwide
    3. References
      1. Hedman (2000) Eur J Ophthalmol 10:95
  5. Adverse Effects
    1. Increased eyelash growth or pigmentation
    2. Altered iris pigmentation

latanoprost (C0090306)

Definition (NCI)A prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC072042
Englishlatanaprost, latanoprost, LATANOPROST PREPARATION
Spanishlatanoprost
Parent ConceptsAnti glaucoma agent (C1515995), Prostaglandins F, Synthetic (C0033562), [OP109] ANTIGLAUCOMA, OTHER (C0973594), Prostaglandins, Synthetic (C0033568), Prostaglanding analog anti glaucoma preparation (C1689940), Prostaglandins, Ophthalmic (C1579383)
SourcesMSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Xalatan (C0593887)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC072042
EnglishPharmacia Brand of Latanoprost, Xalatan
SourcesMSH, MTH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)


UNOPROSTONE (C0772319)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishUNOPROSTONE, UNOPROSTONE PREPARATION
Parent ConceptsUF 021 (C0147728), [OP109] ANTIGLAUCOMA, OTHER (C0973594), Prostaglandins, Ophthalmic (C1579383)
SourcesNDFRT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


travoprost (C0937916)

Definition (NCI)A synthetic lipophilic isopropyl ester prodrug of the active compound travoprost free acid, a prostaglandin F2alpha analog with anti-glaucoma property. Upon administration, travoprost is hydrolysed to a free acid by corneal esterases, and then selectively stimulating the prostaglandin F (FP prostanoid) receptor, thereby increasing the uveoscleral outflow which leads to a reduction in intra-ocular pressure.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC438103
Englishtravoprost, TRAVOPROST @ @ UNIDENTIFIED, TRAVOPROST PREPARATION, TRAVOPROST UNIDENTIFIED
Spanishtravoprost
Parent ConceptsAnti glaucoma agent (C1515995), [OP109] ANTIGLAUCOMA, OTHER (C0973594), Unclassified Ingredients (C1372954), Prostaglandins, Synthetic (C0033568), Prostaglanding analog anti glaucoma preparation (C1689940), Prostaglandins, Ophthalmic (C1579383)
SourcesMSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


bimatoprost (C0937917)

Definition (NCI)A synthetic prostamide and structural prostaglandin analogue with ocular hypotensive activity. Bimatoprost mimics the effects of the endogenous prostamides and reduces intracocular pressure by increasing outflow of aqueous humor through both the pressure-sensitive outflow pathway (the trabecular meshwork), and the pressure-insensitive outflow pathway (the uveoscleral routes). It is not clear whether bimatoprost lowers intraocular pressure by stimulating F-Prostanoid receptors or by acting on specific prostamide receptors.
ConceptsLipid (T119) , Pharmacologic Substance (T121)
MSHC420823
Englishbimatoprost, BIMATOPROST @ @ UNIDENTIFIED, BIMATOPROST PREPARATION, BIMATOPROST UNIDENTIFIED
Spanishbimatoprost
Parent ConceptsAnti glaucoma agent (C1515995), [OP109] ANTIGLAUCOMA, OTHER (C0973594), Unclassified Ingredients (C1372954), Prostaglandins, Synthetic (C0033568), Prostaglanding analog anti glaucoma preparation (C1689940), Prostaglandins, Ophthalmic (C1579383)
SourcesMSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Lumigan (C0939372)

ConceptsLipid (T119) , Pharmacologic Substance (T121)
MSHC420823
EnglishAllergan brand of bimatoprost, Lumigan, Pharm-Allergan brand of bimatoprost
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)


Eescula (C0939466)

ConceptsEicosanoid (T111) , Pharmacologic Substance (T121)
MSHC072630
EnglishCiba Vision brand of isopropyl unoprostone, Eescula, Novartis brand of isopropyl unoprostone, Rescula
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)


Travatan (C0939506)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC438103
EnglishAlcon brand of travoprost, Travatan
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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