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Benign Premature Adrenarche

Pathophysiology
1. Benign self-limited cause of Precocious Puberty
Epidemiology
1. Onset before age 6 years
Signs
1. Early secondary sexual characteristics in children
  1. Early pubic hair and axillary hair development
  2. Increased sebaceous activity
  3. Adult-type body odor
2. No Sexual Development
3. Normal growth pattern
Radiology
1. Bone age consistent chronological age
2. Other imaging studies normal
Labs
1. Slight increase in Serum DHEA level
2. Other adrenal steroid hormones normal
3. Sex hormone levels normal
4. ACTH stimulation test normal
  1. No Congenital Adrenal Hyperplasia
5. GnRH Stimulation Test normal
  1. Consistent with prepubertal pattern
Management
1. Reassurance

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 8/14/2009. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.