Gynecology Book

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Hyperandrogenism

Aka: Hyperandrogenism, Hyperandrogenemia, Androgen Excess
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  1. See Also
    1. Hyperandrogenism Causes
    2. Medication Causes of Hyperandrogenism
    3. Hirsutism
    4. HAIR-AN Syndrome
    5. Polycystic Ovary Disease (Stein-Leventhal Syndrome)
  2. Symptoms and Signs
    1. General appearance
      1. Muscular male body habitus (e.g. Shoulder girdle)
      2. Android Obesity
    2. Miscellaneous Changes
      1. Deepening of voice
      2. Clitorimegaly
      3. Increased Libido
    3. Menstrual irregularity
      1. Amenorrhea
      2. Infertility
    4. Endocrine changes
      1. Hypertension
      2. Hyperlipidemia
      3. Glucose Intolerance
    5. Skin changes
      1. Hirsutism involving face, chin, chest and perineum
      2. Alopecia
        1. Vertex or crown Hair Loss
        2. Bitemporal Hair Loss may also occur
      3. Acanthosis Nigricans (HAIR-AN Syndrome)
      4. Oily skin
      5. Acne Vulgaris
      6. Male sweat changes (malodorous perspiration)
  3. Associated Conditions: Hyperandrogenic Syndromes
    1. HAIR-AN Syndrome
    2. Polycystic Ovary Disease (Stein-Leventhal Syndrome)
  4. Causes
    1. See Hyperandrogenism Causes
    2. See Medication Causes of Hyperandrogenism
  5. Labs
    1. Serum Testosterone (normally 20-80 ng/dl)
      1. Measure on 2 separate occasions
      2. Level <200: Hyperandrogenic chronic Anovulation
      3. Level >200: Assess for virilizing tumor
    2. Serum 17a-Hydroxyprogesterone (normally <2 ng/ml)
      1. Test >4 ng/ml suggests Congenital Adrenal Hyperplasia
      2. Check adrenocorticotropic stimulation test
    3. Dehydroepiandrosterone sulfate (normal 250-300 ng/dl)
      1. DHEAS <700 ng/dl: Hyperandrogenic chronic Anovulation
      2. DHEAS >700 ng/dl: Adrenal tumor secreting androgens
    4. Other labs to consider
      1. Dexamethasone Suppression Test (AM Serum Cortisol)
        1. Assess for Cushing's Syndrome
      2. Luteinizing hormone and Follicle Stimulating Hormone
        1. Assess for ovarian tumors
      3. Lipid profile
        1. Lipids elevated in Hyperandrogenism
  6. References
    1. Elmer (2001) Am Fam Physician 63(12): 2385-90
    2. Redmond (1998) J Fertil Womens Med 43:91-7

Hyperandrogenism (C0206081)

Definition (MSH) A condition caused by the excessive secretion of ANDROGENS from the ADRENAL CORTEX; the OVARIES; or the TESTES. The clinical significance in males is negligible. In women, the common manifestations are HIRSUTISM and VIRILISM as seen in patients with POLYCYSTIC OVARY SYNDROME and ADRENOCORTICAL HYPERFUNCTION.
Concepts Disease or Syndrome (T047)
MSH D017588
SnomedCT 237793004
English Hyperandrogenism, hyperandrogenism, Hyperandrogenism [Disease/Finding], Hyperandrogenisation syndrome, Hyperandrogenization syndrome (disorder), Hyperandrogenization syndrome
Dutch hyperandrogenisme, Androgenisme, hyper-, Hyperandrogenisme
French Hyperandrogénisme, Hyperandrogénie
Japanese アンドロゲン過剰症, ｱﾝﾄﾞﾛｹﾞﾝｶｼﾞｮｳｼｮｳ
Swedish Hyperandrogenism
Czech hyperandrogenismus, Hyperandrogenismus
Finnish Hyperandrogenismi
Russian GIPERANDROGENIZM, ГИПЕРАНДРОГЕНИЗМ
Polish Hiperandrogenizm
Hungarian Hyperandrogenismus
Spanish hiperandrogenismo, síndrome de hiperandrogenización (trastorno), síndrome de hiperandrogenización, Hiperandrogenismo
German Hyperandrogenismus
Italian Iperandrogenismo
Portuguese Hiperandrogenismo
Sources
Derived from the NIH UMLS (Unified Medical Language System)


ANDROGEN EXCESS EFFECT (C0235461)

Concepts Disease or Syndrome (T047)
ICD10 E28.1
French HYPERANDROGENISME, Effet excessivement androgène
English ANDROGEN EXCESS EFFECT, Androgen excess, Androgen excess effect, androgens excess, excess androgen, androgen excess, excess; androgens, androgen; excess
Portuguese HIPERANDROGENISMO, Efeito de excesso de androgénios
Dutch androgeen surpluseffect, androgeen; overmaat, overmaat; androgenen, Overmaat aan androgenen
German Androgenueberschuss Auswirkung, ANDROGENIS-ERSCHEINUNG, Ovarielle Dysfunktion: Androgenueberschuss
Italian Effetto da eccesso di ormoni androgeni
Spanish Efecto por exceso de andrógenos, ANDROGENOS, HIPERACTIVIDAD
Japanese アンドロゲン過剰効果, ｱﾝﾄﾞﾛｹﾞﾝｶｼﾞｮｳｺｳｶ
Czech Účinek nadbytku androgenů
Korean 안드로겐 과다
Hungarian Túlzott androgén hatás
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Hyperandrogenemia (C1299574)

Concepts Finding (T033)
SnomedCT 371131009
English HYPERANDROGENEMIA, Hyperandrogenemia, Hyperandrogenemia (finding)
Spanish hiperandrogenemia (hallazgo), hiperandrogenemia
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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