Endocrinology Book

http://www.fpnotebook.com/

Benign Premature Thelarche

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  1. Pathophysiology
    1. Benign self-limited cause of Precocious Puberty
  2. Epidemiology
    1. Onset as early as age 18 months
  3. Signs
    1. Early breast development (not to mature breast contour)
    2. No other signs of Puberty
    3. Normal prepubertal growth rate
  4. Radiology
    1. Bone age consistent chronological age
    2. Ovarian ultrasound normal
  5. Labs
    1. Serum Gonadotropin levels normal
    2. Serum Estradiol normal
  6. Management
    1. Reassurance
    2. Do not biopsy breast
      1. Biopsy results in partial Mastectomy
      2. Further breast development abnormal post-biopsy
  7. Course
    1. Spontaneous resolution

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