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AndrostenedioneAka: Dehydroepiandrosterone, DHEA

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  1. Epidemiology
    1. Androstenedione banned by IOC, NCAA, NFL
    2. DHEA banned by IOC
  2. Sources
    1. Androgen synthesized by gonads and adrenal gland
      1. Natural intermediaries in endogenous testosterone synthesis from Cholesterol
    2. Used by athletes as performance enhancer
      1. Available in Europe as nasal preparation
      2. Available in U.S. as oral tablet
  3. Pharmacokinetics
    1. Little intrinsic activity
    2. Direct precursor of estrone and testosterone
      1. Increases Nitrogen retention
      2. Increases strength and muscle mass
  4. Adverse Effects (if sustained testosterone increase)
    1. Sustained increase in serum Estrogen
    2. Sustained increase in serum Luteinizing hormone
    3. Decreased HDL Cholesterol
    4. Priapism has occurred in case reports
  5. Efficacy
    1. Controlled studies do not show any strength or performance benefit
      1. Ballantyne (2000) Can J Appl Physiol 25:68
      2. Broeder (2000) Arch Intern Med 160(20):3093
  6. References
    1. King (1999) JAMA 281:2020
    2. Leder (2000) JAMA 283:779

Androstenedione (C0002860)

Definition (MSH)A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.
Definition (CSP)delta-4 C19 steroid that is produced in the testes, ovaries and adrenal cortex and can serve as a precursor to testosterone as well as estrone and estradiol.
Definition (NCI)A steroid hormone synthesized by the adrenal glands and the gonads from either 17-alpha-hydroxyprogesterone or dehydroepiandrosterone and is a precursor of testosterone.
Definition (NCI)A potent androgenic prohormone that is a direct precursor of testosterone and used as a supplement to increase plasma testosterone levels and muscle anabolism. (NCI)
ConceptsSteroid (T110) , Pharmacologic Substance (T121) , Hormone (T125)
MSHD000735
EnglishADD, ADIONE - Delta 4-androstenedione, Androstanedione, Androstenedione, ANDROSTENEDIONE PREPARATION, delta 4 Androstenedione, Delta 4-androstenedione, Delta-4-Androstenedione, Therapeutic Androstenedione
Spanishandrostanediona, androstenediona
Parent ConceptsAndrostenols (C0002864), Androgens (C0002844), 17-Ketosteroids (C0000167), Androstenes (C0002862), Testosterone Congeners (C1257991), Anabolic steroids (C0002744), Unclassified Ingredients (C1372954), Unclassified Ingredient Preparations (C1377282), Androstanes (C0002854), Steroid metabolism disorder marker (C0443588), 11-Deoxy-17-ketosteroid (C0522262), Reason not stated concept (C1276325)
SourcesAOD, CSP, LNC, MSH, MTH, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


dehydroepiandrosterone (C0011185)

Definition (CSP)major C19 steroid produced by the adrenal cortex; also produced in small quantities in the testis and the ovary; dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone; most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion.
Definition (NCI)A substance that is being studied as a cancer prevention drug. It belongs to the family of drugs called steroids.
Definition (MSH)A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
Definition (PDQ)A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42419&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42419&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2265" NCI Thesaurus)
Definition (NCI)A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. (NCI04)
ConceptsSteroid (T110) , Pharmacologic Substance (T121) , Hormone (T125)
MSHD003687
English3beta-Hydroxyandrost-5-en-17-one, 5 Androsten 3 beta hydroxy 17 one, 5-Androsten-3-beta-hydroxy-17-one, Androstenolone, Androstenolone -RETIRED-, Dehydro-3-epiandrosterone, dehydroepiandrosterone, Dehydroepiandrosterone preparation, Dehydroisoandrosterone, DHA - Dehydroepiandrosterone, DHEA, DHEA - Dehydroepiandrosterone, DHEA preparation, DHEA product, Prasterone, Therapeutic Dehydroepiandrosterone
Spanishandrostenolona - RETIRADO -, dehidro - 3 - epiandrosterona, dehidroepiandrosterona, preparado con dihidroepiandrosterona
Parent ConceptsAndrostenols (C0002864), Adrenal Cortex Hormones (C0001617), Androgens (C0002844), 17-Ketosteroids (C0000167), Testosterone Congeners (C1257991), [HS000] HORMONES / SYNTHETICS / MODIFIERS (C0973563), Unclassified Ingredients (C1372954), Androstanes (C0002854), Androgenic precursors (C0443136), 11-Deoxy-17-ketosteroid (C0522262), Reason not stated concept (C1276325)
SourcesAOD, CSP, LNC, MSH, MTH, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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