Endocrinology Book

http://www.fpnotebook.com/

Fludrocortisone

Aka: Fludrocortisone, Florinef
  1. Mechanism
    1. Systemic Corticosteroid
    2. Expands intravascular volume
  2. Indications
    1. Adrenal Insufficiency
    2. Orthostatic Hypotension (some forms)
  3. Adverse Effects
    1. Volume overload
    2. Hypokalemia
    3. Hypomagnesemia
    4. Headache
    5. Edema
    6. Weight gain
    7. Supine Hypertension
  4. References
    1. (2003) Lexi-comp Drug Database

Fludrocortisone (C0016280)

Definition (NCI) A synthetic corticosteroid. It is used to replace steroid hormones normally produced by the adrenal gland.
Definition (NCI) A synthetic corticosteroid with antiinflammatory and antiallergic properties. Fludrocortisone is a mineralocorticoid receptor and glucocorticoid receptor agonist that binds to cytoplasmic receptors, translocates to the nucleus and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2. This prevents the release of arachidonic acid, a precursor to prostaglandins and leukotrienes, both important mediators in the pro-inflammatory response mechanism. In addition, this agent exerts its mineralocorticoid effect on the distal tubules and collecting ducts of the kidney by inducing permease, an enzyme that regulates Na+ permeability in cells, thereby enhancing Na+ reabsorption and water retention as well as increasing K+, H+ excretion.
Definition (MSH) A synthetic mineralocorticoid with anti-inflammatory activity.
Concepts Steroid (T110) , Pharmacologic Substance (T121) , Hormone (T125)
MSH D005438
SnomedCT 116586002, 89192008
English 9 alpha-Fluorohydrocortisone, 9-Fluorocortisol, 9-Fluorohydrocortisone, Fludrocortisone, 9 Fluorocortisol, 9 Fluorohydrocortisone, 9 alpha Fluorohydrocortisone, fludrocortisone, Pregn-4-ene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11beta)-, 9 Fluoro 17 Hydroxycortisone, 9 alpha Fludrohydrocortisone, 9 alpha Fluoro 17 Hydroxycorticosterone, 9 alpha-Fluoro-17-Hydroxycorticosterone, 9-Fluoro-17-Hydroxycortisone, FLUOROCORTISOL 09, Fludrocortisone [Chemical/Ingredient], 9-fluorohydrocortisone, Fludrocortisone preparation, Fludrocortisone (substance), Fludrocortisone preparation (product), Fludrocortisone preparation (substance), FLUDROCORTISONE
Swedish Fludrokortison
Czech fludrokortison
Finnish Fludrokortisoni
Russian FLUDROKORTIZON, 9-FLUOROKORTIZOL, 9-FTORKORTIZOL, 9-ФЛУОРОКОРТИЗОЛ, 9-ФТОРКОРТИЗОЛ, ФЛУДРОКОРТИЗОН
Spanish fludrocortisona (producto), preparado con fludrocortisona (producto), preparado con fludrocortisona, fludrocortisona (sustancia), fludrocortisona, preparado de fludrocortisona (producto), preparado de fludrocortisona (sustancia), preparado de fludrocortisona, 9-Fluorocortisol, Fludrocortisona
Italian 9 alfa-Fluoro-17-idrossicortisone, 9-Fludro-idrocortisone, 9 alfa Fludro-idrocortisone, 9-Fluoro-17-idrossicortisone, 9-Fluorocortisolo, 9-Fluoro-17-idrocortisone, Fludrocortisone
German FLUORCORTISOL 09, 9-Fluorcortisol, Fludrocortison
Polish Fludrokortyzon
Japanese 酢酸フルドロコルチゾン, フルドロコルチゾン, 9-フルオロコーチゾル, フロリネフ
French Fludrocortisone
Portuguese Fludrocortisona, 9-Fluorcortisol
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Florinef (C0060486)

Concepts Steroid (T110) , Pharmacologic Substance (T121)
MSH C034635
English Florinef Acetate, Florinef, Florinef acetate, florinef, florinef acetate, acetate florinef, Bristol-Myers Squibb brand of fludrocortisone 21-acetate, Monarch brand of fludrocortisone 21-acetate, Shire brand of fludrocortisone 21-acetate
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Navigation Tree