II. Indications

  1. Hepatitis C
  2. Respiratory Syncytial Virus (RSV)
    1. Aerosolized Ribavirin used in high risk infants
  3. Acute Hemorrhagic Fever (Intravenous or Oral Ribavirin)
    1. Arenavirus (Lassa Fever, AHF, BHF, VHF)
    2. Bunyaviridae (e.g. Hantavirus, Rift Valley Fever)
  4. Severe Influenza infection
    1. Intravenous or aerosolized

III. Mechanism

  1. Antiviral guanosine analogue

IV. Adverse Effects

  1. Hemolytic Anemia
  2. Teratogenic (Pregnancy Class X)
    1. Men and women need to avoid conception for 6 months

V. Dosing: Chronic Hepatitis C

  1. Dose <75 kg: 400 mg PO qAM and 600 mg PO qPM
  2. Dose >75 kg: 600 mg PO bid
  3. Dose if Hemolytic Anemia: 300 mg bid
  4. Cost: $2500 per 24 week course

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