II. Indications
- Hepatitis C
-
Respiratory Syncytial Virus (RSV)
- Aerosolized Ribavirin used in high risk infants
- Acute Hemorrhagic Fever (Intravenous or Oral Ribavirin)
- Arenavirus (Lassa Fever, AHF, BHF, VHF)
- Bunyaviridae (e.g. Hantavirus, Rift Valley Fever)
- Severe Influenza infection
- Intravenous or aerosolized
III. Mechanism
- Antiviral guanosine analogue
IV. Adverse Effects
- Hemolytic Anemia
-
Teratogenic (Pregnancy Class X)
- Men and women need to avoid conception for 6 months
V. Dosing: Chronic Hepatitis C
- Dose <75 kg: 400 mg PO qAM and 600 mg PO qPM
- Dose >75 kg: 600 mg PO bid
- Dose if Hemolytic Anemia: 300 mg bid
- Cost: $2500 per 24 week course