Azathioprine

Aka: Azathioprine, Imuran

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II. Indications

  1. Renal homograft maintenance
  2. Myasthenia Gravis
  3. Systemic Lupus Erythematosus (Lupus Nephritis)
  4. Acute Glomerulonephritis

III. Pharmacology

  1. Imidazolyl derivative of mercaptopurine
    1. Metabolized to mercaptopurine as active ingredient
  2. Structural Analogue Chemotherapy (Purine)

IV. Adverse Effects (similar to mercaptopurine)

  1. Bone Marrow suppression
    1. Severe Leukopenia
    2. Anemia
    3. Thrombocytopenia
  2. Skin rash
  3. Drug Fever
  4. Nausea, Vomiting or Diarrhea
  5. Hepatic dysfunction (cholestasis, hepatitis)
  6. Pancreatitis

V. Drug Interactions

  1. See Cytochrome P-450 3A4
  2. See Purine Synthesis Inhibitor
  3. Allopurinol may increase Azathioprine to toxic levels

VI. Monitoring

  1. Complete Blood Count
  2. Liver Function Tests

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Related Studies

Cost: Medications

azathioprine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
AZATHIOPRINE 50 MG TABLET Generic $0.19 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Pharmacology

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