Albendazole

Aka: Albendazole, Albenza

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II. Indications

  1. Tapeworm infections (Hydatid Disease, Neurocysticercosis)

III. Contraindications

  1. Pregnancy

IV. Mechanism

  1. Broad-spectrum, synthetic benzimidazole-derivative anthelminth
  2. Albendazole blocks Helminth reproduction and survival
    1. Inhibits formation of microtubules from tubulin
    2. Depletes glycogen stores (by decreasing Glucose uptake)

V. Medications

  1. Albendazole Tablet 200 mg
    1. Tablet may be crushed or chewed

VI. Dosing: FDA Approved Indications

  1. Hydatid Disease (Echinococcus)
    1. Weight <60 kg: 15 mg/kg/day (up to 800 mg) orally divided twice daily with food
    2. Weight >60 kg: 400 mg orally twice daily with food
  2. Neurocysticercosis
    1. Take 15 mg/kg/day (up to 1200 mg) orally divided twice daily with food for 10 to 14 days
    2. Corticosteroid started before treatment
    3. Multidrug regimens (e.g. with Praziquantel) are used when more than 2 CNS Lesions are present

VII. Dosing: Unapproved Indications

  1. Hookworm, Whipworm, Pinworm or roundworm (age >=2 years)
    1. Take 400 mg for one dose (for Pinworm, repeat dose in 2 weeks)
  2. Cutaneous Larva Migrans (age >=2 years)
    1. Take 200 mg orally twice daily for 3 day with food (or 400 mg once daily for 3 days)
  3. Giardiasis
    1. Take 400 mg orally daily for 5 days with food

VIII. Adverse Effects

  1. Serious
    1. Bone Marrow suppression
    2. Increased Liver Function Tests

IX. Monitoring

  1. Check Complete Blood Count and Liver Function Tests at start and again every 2 weeks

X. Safety

  1. Unknown safety in Lactation
  2. Contraindicated in pregnancy first trimester (unknown safety in later pregnancy)

XI. Resources

  1. Albendazole Tablet (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6c48fd89-cb40-477c-8a78-15cbe0df6faa

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Related Studies

Cost: Medications

albendazole (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
ALBENDAZOLE 200 MG TABLET Generic $13.95 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Pharmacology

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