Silodosin

Aka: Silodosin, Rapaflo ( C2366232)

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II. Indications

  1. Benign Prostatic Hypertrophy
  2. Medical Expulsive Therapy for Ureteral Stone (Ureterolithiasis)

III. Contraindications

  1. Chronic Kidney Disease Stage 4 (GFR <30 ml/min)
  2. Severe liver disease (Child-Pugh Score 10 or more)

IV. Dosing

  1. Take 8 mg daily with food
  2. Limit dose to 4 mg daily if GFR 30-50 ml/min

V. Adverse Effects

  1. See Selective Alpha-1a Antagonist
  2. Postural Hypotension (esp. when combined with Antihypertensives)
  3. Floppy Iris Syndrome
  4. Ejaculatory Dysfunction (class effect)

VI. Drug Interactions

  1. Avoid all Selective Alpha-1a Antagonists with strong CYP3A4 inhibitors (e.g. Ketoconazole, Clarithromycin, Itraconazole, Ritonavir)
  2. Avoid Silodosin with strong P-Glycoprotein Inhibitors

VII. Resources

  1. Silodosin (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=96425d91-cfe1-477d-a130-b58c330ca8a3

VIII. References

  1. Hamilton (2020) Tarascon Pharmacopoeia, Jones and Bartlett, Boston
  2. Nachawati (2022) Alpha Blockers, StatPearls, Treasure Island, FL, accessed 12/25/2022
    1. https://www.ncbi.nlm.nih.gov/books/NBK556066/

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Cost: Medications

silodosin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
SILODOSIN 4 MG CAPSULE Generic $0.45 each
SILODOSIN 8 MG CAPSULE Generic $0.63 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Pharmacology

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