II. Indications

  1. Insomnia (as adjunct to SSRI)
  2. Impotence
    1. See Impotence Management for more effective agents

III. Mechanism

  1. Triazolopyridine derivative
  2. Unrelated to Tricyclic Antidepressants
  3. Phenylpiperazine Antidepressant (Serzone prototype)
  4. Serotonin Antagonist and Reuptake Inhibitor (SARI)
    1. Blocks 5-HT-2 postsynaptic receptor
    2. Low dose: Serotonin receptor antagonist
    3. High dose: Serotonin Agonist
    4. Weaker than SSRIs as a Serotonin reuptake inhibitor

IV. Pharmacokinetics

  1. Serum Half Life: 4 to 9 hours
  2. Therapeutic plasma level: 800 to 1600

V. Efficacy: Major Depression

VI. Background

  1. Cost: $34 per month (generic)

VII. Dosing

  1. Sleep
    1. Dose: 25-100 mg PO qhs
    2. Average: 50 mg PO qhs
  2. Major Depression
    1. Start: 50 to 150 mg per day in divided doses
    2. Effective dose: 400 to 600 mg in divided doses

VIII. Adverse Effects

  1. Sedation
    1. Limits use as an Antidepressant
    2. Useful in Major Depression with Insomnia
  2. Priapism (See Priapism Management)
  3. Serotonin Syndrome
  4. Cardiac arrhythmia
  5. Orthostatic Hypotension (Dizziness)
    1. Minimize by administering with food

IX. Drug Interaction

  1. Increased serum Digoxin level
  2. Increased Phenytoin level

X. Toxicity

XI. References

  1. Sundberg (1995) Depression Primary Care, PGM, p. 45-57

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Cost: Medications

TRAZODONE (on 2/19/2015 at Target.com)
TRAZODONE 100 MG Tablet #90 for $10.00 $0.11 each
TRAZODONE 150 MG Tablet #90 for $10.00 $0.11 each
TRAZODONE 50 MG Tablet #90 for $10.00 $0.11 each
trazodone (on 7/20/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
TRAZODONE 100 MG TABLET Generic $0.10 each
TRAZODONE 150 MG TABLET Generic $0.24 each
TRAZODONE 300 MG TABLET Generic $3.59 each
TRAZODONE 50 MG TABLET Generic $0.06 each

Ontology: Trazodone (C0040805)

Definition (CHV) a kind of depression treatment drug
Definition (CHV) a kind of depression treatment drug
Definition (NCI) A synthetic triazolopyridine derivative, antidepressant and sedative Trazodone acts as a serotonin uptake inhibitor, chemically unrelated to tricyclic, tetracyclic, or other antidepressants. It is effective in patients with schizoaffective disorders; major depressive disorders; and depressive disorders associated with insomnia and anxiety. (NCI04)
Definition (MSH) A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D014196
SnomedCT 372829000, 7336002
LNC LP16297-1, MTHU005053
English Tradozone, Trazodone, 1,2,4-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-, Searle Brand of Trazodone Hydrochloride, Trazodone [Chemical/Ingredient], tradozone, traZODone, TRAZODONE, trazodone, Trazodone (product), Trazodone (substance)
Swedish Trazodon
Czech trazodon
Finnish Tratsodoni
Russian TRAZODON, ТРАЗОДОН
Japanese トラゾドン
Polish Trazodon
Spanish trazodona (producto), trazodona (sustancia), trazodona, Trazodona
French Trazodone
German Trazodon
Italian Trazodone
Portuguese Trazodona

Ontology: Desyrel (C0701914)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D014196
English desyrel, Desyrel, Apothecon Brand of Trazodone Hydrochloride, Bristol Myers Squibb Brand of Trazodone Hydrochloride, Bristol-Myers Squibb Brand of Trazodone Hydrochloride