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DesyrelAka: Trazodone

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  1. Indications
    1. Insomnia (as adjunct to SSRI)
    2. Impotence
      1. See Impotence Management for more effective agents
  2. Mechanism
    1. Triazolopyridine derivative
    2. Unrelated to Tricyclic Antidepressants
    3. Phenylpiperazine Antidepressant (Serzone prototype)
    4. Serotonin Antagonist and Reuptake Inhibitor (SARI)
      1. Blocks 5-HT-2 postsynaptic receptor
      2. Low dose: Serotonin receptor antagonist
      3. High dose: Serotonin Agonist
      4. Weaker than SSRIs as a Serotonin reuptake inhibitor
  3. Pharmacokinetics
    1. Serum Half Life: 4 to 9 hours
    2. Therapeutic plasma level: 800 to 1600
  4. Efficacy: Major Depression
    1. As effective as Fluoxetine, Tricyclic Antidepressants
  5. Background
    1. Cost: $34 per month (generic)
  6. Dosing
    1. Sleep
      1. Dose: 25-100 mg PO qhs
      2. Average: 50 mg PO qhs
    2. Major Depression
      1. Start: 50 to 150 mg per day in divided doses
      2. Effective dose: 400 to 600 mg in divided doses
  7. Adverse Effects
    1. Sedation
      1. Limits use as an Antidepressant
      2. Useful in Major Depression with Insomnia
    2. Priapism (See Priapism Management)
    3. Serotonin Syndrome
    4. Cardiac arrhythmia
    5. Orthostatic Hypotension (Dizziness)
      1. Minimize by administering with food
  8. Drug Interaction
    1. Increased serum Digoxin level
    2. Increased Phenytoin level
  9. Toxicity
    1. Less toxic in overdose than Tricyclic Antidepressants
    2. Lower Incidence of Anticholinergic Toxicity
  10. References
    1. Sundberg (1995) Depression Primary Care, PGM, p. 45-57

Trazodone (C0040805)

Definition (MSH)A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
Definition (NCI)A synthetic triazolopyridine derivative, antidepressant and sedative Trazodone acts as a serotonin uptake inhibitor, chemically unrelated to tricyclic, tetracyclic, or other antidepressants. It is effective in patients with schizoaffective disorders; major depressive disorders; and depressive disorders associated with insomnia and anxiety. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD014196
EnglishSearle Brand of Trazodone Hydrochloride, Tradozone, Trazodone, TRAZODONE PREPARATION
Spanishtrazodona
Parent Conceptspiperazine (C0031957), Piperazines (C0031958), Pyridones (C0034260), Antidepressive Agents (C0003289), [CN609] ANTIDEPRESSANTS, OTHER (C0973506), Triazolopyridine (C1271027), Phenylpiperazine antidepressant (C1445647), ANTIDEPRESSANTS,OTHER (C1579362)
SourcesAOD, LNC, MSH, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Desyrel (C0701914)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD014196
EnglishApothecon Brand of Trazodone Hydrochloride, Bristol Myers Squibb Brand of Trazodone Hydrochloride, Bristol-Myers Squibb Brand of Trazodone Hydrochloride, Desyrel
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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