I. Indications

  1. Insomnia (as adjunct to SSRI)
  2. Impotence
    1. See Impotence Management for more effective agents

II. Mechanism

  1. Triazolopyridine derivative
  2. Unrelated to Tricyclic Antidepressants
  3. Phenylpiperazine Antidepressant (Serzone prototype)
  4. Serotonin Antagonist and Reuptake Inhibitor (SARI)
    1. Blocks 5-HT-2 postsynaptic receptor
    2. Low dose: Serotonin receptor antagonist
    3. High dose: Serotonin Agonist
    4. Weaker than SSRIs as a Serotonin reuptake inhibitor

III. Pharmacokinetics

  1. Serum Half Life: 4 to 9 hours
  2. Therapeutic plasma level: 800 to 1600

IV. Efficacy: Major Depression

V. Background

  1. Cost: $34 per month (generic)

VI. Dosing

  1. Sleep
    1. Dose: 25-100 mg PO qhs
    2. Average: 50 mg PO qhs
  2. Major Depression
    1. Start: 50 to 150 mg per day in divided doses
    2. Effective dose: 400 to 600 mg in divided doses

VII. Adverse Effects

  1. Sedation
    1. Limits use as an Antidepressant
    2. Useful in Major Depression with Insomnia
  2. Priapism (See Priapism Management)
  3. Serotonin Syndrome
  4. Cardiac arrhythmia
  5. Orthostatic Hypotension (Dizziness)
    1. Minimize by administering with food

VIII. Drug Interaction

  1. Increased serum Digoxin level
  2. Increased Phenytoin level

IX. Toxicity

X. References

  1. Sundberg (1995) Depression Primary Care, PGM, p. 45-57

Images: Related links to external sites (from Google)

Cost: Medications

TRAZODONE (on 2/10/2012 at Target.com)
TRAZODONE 50 MG Tablet #30 for $4.00 ($0.13/unit)
TRAZODONE 100 MG Tablet #30 for $4.00 ($0.13/unit)
TRAZODONE 150 MG Tablet #30 for $4.00 ($0.13/unit)
TraZODone HCl (on 2/9/2012 at DrugStore.com)
TraZODone HCl 300mg Tablets #100 for $402.20 ($4.02/unit)
TraZODone HCl 50mg Tablets #30 for $11.99 ($0.40/unit)
TraZODone HCl 100mg Tablets #30 for $13.99 ($0.47/unit)
TraZODone HCl 150mg Tablets #30 for $20.87 ($0.70/unit)

Ontology: Trazodone (C0040805)

Definition (CHV) a kind of depression treatment drug
Definition (CHV) a kind of depression treatment drug
Definition (MSH) A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
Definition (NCI) A synthetic triazolopyridine derivative, antidepressant and sedative Trazodone acts as a serotonin uptake inhibitor, chemically unrelated to tricyclic, tetracyclic, or other antidepressants. It is effective in patients with schizoaffective disorders; major depressive disorders; and depressive disorders associated with insomnia and anxiety. (NCI04)
Concepts Organic Chemical (T109) , Pharmacologic Substance(T121)
MSH D014196
SnomedCT 372829000, 7336002
English Tradozone, Trazodone, 1,2,4-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-, Searle Brand of Trazodone Hydrochloride, traZODONE, Trazodone [Chemical/Ingredient], tradozone, trazodone, traZODone, Trazodone (product), Trazodone (substance), TRAZODONE
Swedish Trazodon
Czech trazodon
Finnish Tratsodoni
Russian TRAZODON, ТРАЗОДОН
Japanese トラゾドン
Polish Trazodon
Spanish trazodona (producto), trazodona (sustancia), trazodona, Trazodona
French Trazodone
German Trazodon
Italian Trazodone
Portuguese Trazodona

Ontology: Desyrel (C0701914)

Concepts Organic Chemical (T109) , Pharmacologic Substance(T121)
MSH D014196
English desyrel, desyrels, Desyrel, Apothecon Brand of Trazodone Hydrochloride, Bristol Myers Squibb Brand of Trazodone Hydrochloride, Bristol-Myers Squibb Brand of Trazodone Hydrochloride