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KavaAka: Kava Kava

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  1. Indications
    1. Anxiety Disorder
  2. Mechanism
    1. Potentiates GABA neurotransmitters
  3. Adverse Effects
    1. Serious Extrapyramidal Side Effects
    2. Excessive Sedation when used with other CNS depressants
    3. May exacerbate Parkinson's Disease
    4. Platelet Dysfunction
    5. Dermopathy or Photosensitivity
      1. Pruritic Red Papules and Plaques
      2. May be related to Sun Exposure after kava ingestion
    6. Hepatotoxicity
      1. Unclear mechanism and incomplete data
      2. Some cases progressed to liver failure
      3. Anke (2004) Planta Med 70(3):193
  4. Drug Interactions
    1. Multiple cytochrome P450 interactions
    2. Additive effects with CNS Depressants
      1. Benzodiazepines
      2. Barbiturates
      3. Antipsychotics
      4. Alcohol
  5. Precautions
    1. Avoid use longer than 24 weeks
    2. Discontinue at least 24 hours before surgery
      1. May potentiate perioperative anesthesia
  6. Efficacy
    1. Mildly effective in Anxiety Disorder
      1. Witte (2005) Phytother Res 19:183
  7. References
    1. Ang-Lee (2001) JAMA 286:208
    2. Cupp (1999) Am Fam Physician 59(5):1239

Kava preparation (C0939882)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishKAVA, Kava extract, KAVA EXTRACT PREPARATION, Kava kava, Kava preparation, Piper Methysticum
Spanishextracto de kava, preparacion con kava
Parent ConceptsKava preparation (C0939882), Unclassified Ingredients (C1372954), Unclassified Ingredient Preparations (C1377282), Medicinal Herbs (C0025125), Plant product (C0032088), Over the counter healthfood/herbal products (C0361218), Drug allergen (C1320237), Herbal medicine agent (C1636187)
SourcesMTH, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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