Pharmacology Book

http://www.fpnotebook.com/

Evening Primrose OilAka: Oenothera biennis

Advertisement

  1. Mechanism
    1. Seeds contain essential fatty acid
      1. Linoleic Acid
      2. Gamma-linolenic acid (GLA), a Omega 6 fatty acid
    2. Linoleic Acid is precursor to Prostaglandin E
      1. May replace deficiency in Premenstrual Syndrome
  2. Contraindications
    1. Seizure disorder
    2. Concurrent Antipsychotic medication
  3. Current use
    1. Mastalgia (especially cyclical Breast Pain)
      1. Premenstrual Syndrome
      2. Menopause
    2. Other experimental areas
      1. Atopic Dermatitis
      2. Diabetic Neuropathy
      3. Rheumatoid Arthritis
  4. Dosing
    1. Evening Primrose Oil 500 mg capsules, 6 per day
  5. Adverse Effects
    1. Well tolerated
    2. Nausea
    3. Stool softening
    4. Headache
    5. May predispose to Seizure disorder
  6. Disadvantages
    1. Expensive: 25 cents per capsule ($1.50 per day)
  7. Efficacy
    1. Variable results in studies
  8. References
    1. Chenoy (1994) :
    2. Pye (1985) Lancet 2:373

Navigation Tree