Pulmonology Book

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Bronchiolitis Obliterans

Aka: Bronchiolitis Obliterans
  1. See Also
    1. Bronchiolitis Obliterans with Organizing Pneumonia
  2. Pathophysiology
    1. Obstruction of Bronchioles by granulation tissue
    2. Triggered by injury to Bronchiolar epithelium
      1. Response to Bronchiolar reinjury during repair phase
      2. Results in excessive granulation tissue proliferation
  3. Causes
    1. Inhalation of toxic fumes
    2. Exposure to mineral dust
    3. Transplantation
      1. Bone Marrow transplant with graft-versus-host disease
      2. Heart-Lung Transplantation
    4. Hypersensitivity pneumonitis
    5. Medications: Penicillamine
    6. Infection
      1. Mycoplasma pneumoniae
      2. Legionella
      3. Viral respiratory infections
    7. Rheumatologic Conditions
      1. Rheumatoid Arthritis
      2. Systemic Lupus Erythematosus
      3. Dermatomyositis
      4. Polymyositis
  4. Symptoms
    1. Non-productive cough with Dyspnea
    2. Onset 2-8 weeks after respiratory injury (see causes)
  5. Signs
    1. Expiratory Wheezes
  6. Imaging: Chest XRay
    1. Variable pattern (may be normal)
    2. Diffuse nodular pattern
    3. Distal hyperinflation

Bronchiolitis Obliterans (C0006272)

Definition (MSH) Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
Definition (NCI) A condition in which the bronchioles (tiny branches of air tubes in the lungs) become inflamed and blocked. It may be caused by breathing in gases or particles that irritate the bronchioles. This irritation causes scar tissue to form, and makes breathing difficult. Bronchiolitis olbiterans may be caused by other factors, and can also occur after a transplant with an organ or stem cells from a matched donor.
Definition (NCI) Inflammation of the bronchioles with obstruction by fibrous granulation tissue or bronchial exudate. It may follow inhalation of irritating gases or foreign bodies and it complicates pneumonia.
Concepts Disease or Syndrome (T047)
MSH D001989
SnomedCT 31886003, 40100001
English BRONCHIOLITIS OBLITERANS, OBLITERATIVE BRONCHIOLITIS, Obliterative bronchiolitis, NOS, OB - Obliterativ bronchiolitis, BO, Bronchiolitis Obliterans, obliterative bronchiolitis, bronchiolitis obliterans, bronchiolitis obliterans (diagnosis), obliterative bronchiolitis (diagnosis), Bronchiolitis Obliterans [Disease/Finding], bronchiolitis obliteran, bronchiolitis obliterative, Bronchiolitis fibrosa obliterans, Bronchiolitis obliterans, OB - Obliterative bronchiolitis, Obliterative bronchiolitis, Bronchiolitis fibrosa obliterans (disorder), Obliterative bronchiolitis (disorder), bronchiolitis; fibrosa obliterans, bronchiolitis; obliterative, fibrosa obliterans; bronchiolitis, obliterative; bronchiolitis
Italian Bronchiolote obliterativa, Bronchiolite proliferativa, Bronchiolite essudativa, Bronchiolite obliterante
Swedish Obliterativ bronkiolit
Japanese ﾍｲｿｸｾｲｻｲｷｶﾝｼｴﾝ, 細気管支炎-滲出性, 細気管支炎-閉塞性, 増殖性細気管支炎, 滲出性細気管支炎, 閉塞性細気管支炎, 閉鎖性気管支炎, 細気管支炎-増殖性
Czech bronchiolitida obliterující, Bronchiolitida obliterující, Obliterující bronchiolitida
Finnish Tukkeava bronkioliitti
Russian BRONKHIOLIT EKSSUDATIVNYI, BRONKHIOLIT PROLIFERATIVNYI, BRONKHIOLIT OBLITERIRUIUSHCHII, БРОНХИОЛИТ ОБЛИТЕРИРУЮЩИЙ, БРОНХИОЛИТ ПРОЛИФЕРАТИВНЫЙ, БРОНХИОЛИТ ЭКССУДАТИВНЫЙ
Polish Zespół zarostowego zapalenia oskrzelików, Zapalenie oskrzelików zarostowe, Zarostowe zapalenie oskrzelików
Hungarian Bronchiolitis obliterans, Obliterativ bronchiolitis
Dutch bronchiolitis; fibrosa obliterans, bronchiolitis; obliteratief, fibrosa obliterans; bronchiolitis, obliteratief; bronchiolitis, bronchiolitis obliterans, Bronchiolitis obliterans, Bronchiolitis, exsudatieve, Bronchiolitis, proliferatieve
Spanish bronquiolitis fibrosa obliterante (trastorno), bronquiolitis fibrosa obliterante, bronquiolitis obliterante (trastorno), bronquiolitis obliterante, Bronquiolitis obliterante, Bronquiolitis Obliterante
Portuguese Bronquiolite obliterante, Bronquiolite Obliterante
German obliterative Bronchiolitis, Bronchiolitis obliterans, Bronchiolitis, exsudative, Bronchiolitis, obliterierende, Bronchiolitis, proliferative
French Bronchiolite oblitérante
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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