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Bronchiolitis Obliterans

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  1. See Also
    1. Bronchiolitis Obliterans with Organizing Pneumonia
  2. Pathophysiology
    1. Obstruction of bronchioles by granulation tissue
    2. Triggered by injury to bronchiolar epithelium
      1. Response to bronchiolar reinjury during repair phase
      2. Results in excessive granulation tissue proliferation
  3. Causes
    1. Inhalation of toxic fumes
    2. Exposure to mineral dust
    3. Transplantation
      1. Bone Marrow transplant with graft-versus-host disease
      2. Heart-Lung Transplantation
    4. Hypersensitivity pneumonitis
    5. Medications: Penicillamine
    6. Infection
      1. Mycoplasma pneumoniae
      2. Legionella
      3. Viral respiratory infections
    7. Rheumatologic Conditions
      1. Rheumatoid Arthritis
      2. Systemic Lupus Erythematosus
      3. Dermatomyositis
      4. Polymyositis
  4. Symptoms
    1. Non-productive cough with Dyspnea
    2. Onset 2-8 weeks after respiratory injury (see causes)
  5. Signs
    1. Expiratory Wheezes
  6. Imaging: Chest XRay
    1. Variable pattern (may be normal)
    2. Diffuse nodular pattern
    3. Distal hyperinflation

Bronchiolitis Obliterans (C0006272)

Definition (MSH)Inflammation of the bronchioles with obstruction by fibrous granulation tissue or bronchial exudate. It may follow inhalation of irritating gases or foreign bodies and it complicates pneumonia.
Definition (NCI)Inflammation of the bronchioles with obstruction by fibrous granulation tissue or bronchial exudate. It may follow inhalation of irritating gases or foreign bodies and it complicates pneumonia.
ConceptsDisease or Syndrome (T047)
MSHD001989
EnglishBO, Bronchiolitis exudativa, Bronchiolitis fibrosa obliterans, Bronchiolitis Obliterans, Exudative Bronchiolitides, Exudative Bronchiolitis, OB - Obliterative bronchiolitis, OBLITERATIVE BRONCHIOLITIS, Proliferative Bronchiolitides, Proliferative Bronchiolitis
Spanishbronquiolitis exudativa, bronquiolitis fibrosa obliterante, bronquiolitis obliterante
Parent ConceptsBronchiolitis (C0006271), Lung Diseases, Interstitial (C0206062), Airway Obstruction (C0001883), Bronchiolitis Obliterans (C0006272), Chronic Obstructive Airway Disease (C0024117), Obstruction of lower respiratory tract (C1960171)
SourcesDXP, MSH, MTH, NCI, NDFRT, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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