Infectious Disease Book

http://www.fpnotebook.com/

ValacyclovirAka: Valtrex

Advertisement

  1. Indications
    1. Herpes Zoster (Shingles)
    2. Genital Herpes (initial, recurrent or prophylaxis)
    3. Herpes Labialis (Oral Herpes)
  2. Dosing
    1. Herpes Labialis (Cold Sores)
      1. Adult: 2 grams PO q12 hours for 1 day
    2. Herpes Zoster (Shingles)
      1. Adult: 1 gram tid for 7 days
    3. Genital Herpes
      1. Initial: 1 gram PO bid for 10 days
      2. Recurrent: 500 mg PO bid for 3 days
      3. Prophylaxis (for up to 1 year)
        1. Immunocompetent (<9 episodes/year): 500 mg PO qd
        2. Immunocompetent (9 or more per year): 1000 mg PO qd
        3. HIV with CD4>100: 500 mg PO bid
  3. Adverse Effects
    1. Nausea or Vomiting
    2. Headache
    3. Dizziness

valacyclovir (C0249458)

Definition (CSP)used in the management of herpes simplex virus and varicella zoster virus infections and the prophylaxis of human cytomegalovirus infections.
Definition (NCI)A substance that is being studied in the prevention of fungal, bacterial, and viral infections in patients undergoing donor stem cell transplantation with cells that are infected with cytomegalovirus. It belongs to the family of drugs called antivirals.
Definition (PDQ)A synthetic valyl ester derivative of acyclovir, the antiviral valacyclovir is an acyclovir prodrug that, after metabolization, inhibits viral DNA replication through interference with thymidine kinase. It is used in the management of herpes simplex and varicella zoster infections, as well as prophylactically for human cytomegalovirus infections. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=257236&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=257236&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28235" NCI Thesaurus)
Definition (NCI)A synthetic valyl ester derivative of acyclovir, antiviral Valacyclovir is an acyclovir prodrug that, after metabolization, inhibits viral DNA replication through interference with thymidine kinase. It is used in the management of herpes simplex and varicella zoster infections, as well as prophylactically for human cytomegalovirus infections. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC084555
Englishvalaciclovir, Valaciclovir product, valacyclovir, VALACYCLOVIR PREPARATION, Valacyclovir product
Spanishproducto con valaciclovir, valaciclovir
Parent ConceptsAntiviral Agents (C0003451), Nucleic Acid Synthesis Inhibitors (C0376568), Acyclovir (C0001367), Valine (C0042285), Guanine nucleoside analog (C1319305), Antiherpetic Agents (C1579418)
SourcesCSP, MSH, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Valtrex (C0592245)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC084555
EnglishValtrex
SourcesCSP, MSH, NCI, PDQ, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



Navigation Tree