II. Indications

  1. Herpes Zoster (Shingles)
  2. Recurrent Genital Herpes
  3. Recurrent HSV in immunocompromised patients

III. Dosing

  1. Herpes Zoster (Shingles)
    1. Adult: 500 mg PO q8 hours for 7 days
  2. Genital Herpes
    1. Initial: 250 mg PO tid for 7-10 days
    2. Recurrent immunocompetent: 125 mg PO bid for 5 days
    3. Recurrent in HIV: 500 mg PO bid for 7 days
    4. Prophylaxis: 250 mg PO bid for up to 12 months

IV. Pharmacokinetics

  1. Adjust dose for Creatinine Clearance <60 ml/min

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Cost: Medications

famciclovir (on 12/21/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
FAMCICLOVIR 125 MG TABLET Generic $0.80 each
FAMCICLOVIR 250 MG TABLET Generic $0.52 each
FAMCICLOVIR 500 MG TABLET Generic $0.97 each

Ontology: famciclovir (C0209227)

Definition (NCI) A diacetyl 6-deoxy prodrug analog of the antiviral agent penciclovir. Orally administered, famciclovir in vivo is converted to penciclovir triphosphate, which is active against the Herpes viruses, including herpes simplex 1 and 2 and varicella-zoster. This agent inhibits the replication of viral DNA by interfering competitively with DNA polymerase. (NCI04)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C060590
SnomedCT 387557001, 96097002
LNC LP157326-2, MTHU045606
English 9-(4-acetoxy-3-(acetoxymethyl)but-1-yl)-2-aminopurine, famciclovir, famciclovir (medication), FAMCICLOVIR, famciclovir [Chemical/Ingredient], 2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol Diacetate (ester), Famciclovir, Famciclovir product, Famciclovir (substance), Famciclovir (product)
Spanish famciclovir (producto), famciclovir (sustancia), famciclovir

Ontology: Famvir (C0591478)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C060590
English Famvir, famvir