II. Contraindications

  1. HLA-B*5701 positive state (screen in advance of starting)
    1. Associated with life-threatening hypersensitivity

IV. Dosing

  1. Abacavir 300 mg PO bid

V. Precautions

  1. Do not use unless patient is negative for HLA-B5701
    1. Risk of Hypersensitivity Reaction if HLA-B5701 positive
    2. Lucas (2007) J Antimicrob Chemother 59(4):591-3 +PMID:17317695 [PubMed]

VI. Adverse Effects

  1. Hypersensitivity (3%)
    1. Presents with Fever and Rash
    2. Associated with HLA-B*5701 positive state
    3. Mean onset 11 days after start
    4. Lethal reaction if restarted after reaction (50%)
    5. Never rechallenge Abacavir after reaction
  2. Cardiovascular risk
    1. Unclear association is being investigated

VII. Resources: Abacavir Hypersensitivity Registry

  1. Phone: 1-800-270-0425

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Cost: Medications

abacavir (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
ABACAVIR 300 MG TABLET Generic $2.13 each
ABACAVIR-LAMIVUDINE 600-300 MG Generic $20.22 each
ABACAVIR-LAMIVUDINE-ZIDOV TAB Generic $23.45 each
ziagen (on 5/18/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
ZIAGEN 300 MG TABLET Generic $2.13 each

Ontology: abacavir (C0663655)

Definition (NCI) A nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS.
Definition (CSP) carbocyclic nucleoside with anti-HIV activity.
Concepts Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114)
MSH C106538
SnomedCT 391696008, 387005008, 116084008
LNC LP21306-3, MTHU013841
English abacavir, abacavir [Chemical/Ingredient], AVACAVIR, 2-Cyclopentene-1-methanol, 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-, (1S,4R)-, Abacavir - chemical (substance), Abacavir - chemical, ABACAVIR, Abacavir (product), Abacavir (substance), Abacavir
Spanish abacavir (producto), abacavir (sustancia), abacavir

Ontology: Ziagen (C0724476)

Concepts Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114)
MSH C106538
English Ziagen, GSK brand of abacavir sulfate, ziagen