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Subacute Lymphocytic ThyroiditisAka: Silent Sporadic Thyroiditis, Painless Sporadic Thyroiditis

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  1. Pathophysiology
    1. Autoimmune lymphocytic infiltrate
  2. Epidemiology
    1. More common in women by 4 fold
  3. Signs
    1. Goiter (50%)
    2. Hyperthyroidism (up tp 20%)
      1. Duration: Typically <4 months
      2. Followed by Hypothyroidism and then euthyroid
  4. Differential Diagnosis
    1. Postpartum Thyroiditis
      1. Nearly identical, except limited to postpartum period
    2. Hashimoto's Thyroiditis
      1. Similar, except pathology (Fibrosis, Hurthle Cells)
    3. Grave's Disease
      1. Presents with pretibial edema, Proptosis
    4. Subacute Thyroiditis
      1. Painful Thyroiditis
  5. Labs
    1. Thyroid Function Tests (T4 Free and TSH)
    2. Antibodies
      1. Antithyroid Peroxidase Antibody (positive in 50%)
      2. Thyroid Stimulating Immunoglobulins absent
        1. Contrast with Grave's Disease
  6. Imaging
    1. Radioiodine Uptake (Thyroid uptake and scan)
      1. Low uptake (contrast with Grave's Disease)
  7. Course
    1. Resolves within 1 year in most cases
  8. References
    1. Bindra (2006) Am Fam Physician 73(10):1769

Subacute lymphocytic thyroiditis (C1306804)

ConceptsDisease or Syndrome (T047)
EnglishSubacute lymphocytic thyroiditis
Spanishtiroiditis linfocitica subaguda
Parent ConceptsSubacute thyroiditis (C0040149), Hashimoto Disease (C0677607), Ambiguous concept (C1274012)
SourcesNCI, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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