Dermatology Book

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Clostridium perfringens

Aka: Clostridium perfringens, Gas Gangrene, Anaerobic Cellulitis, Clostridial Myonecrosis
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  1. See also
    1. Cellulitis
  2. Etiology: Clostridium Species
    1. Clostridium perfringens (Clostridium welchii)
    2. Clostridium novyi
    3. Clostridium septicum
    4. Clostridium sordellii
    5. Clostridium histolyticum
  3. Pathophysiology
    1. Tissue infection with gas-producing Anaerobic Bacteria
  4. Symptoms and Signs
    1. Skin wound progression
      1. History of deep contaminated wound (Surgery, Trauma)
      2. Onset Sudden pain at wound site
      3. Local swelling and edema of wound site
      4. Thin hemorrhagic exudate
    2. Toxemia
    3. Hypotension
    4. Renal Failure
    5. Fever
    6. Foul discharge from wound
    7. Subcutaneous crepitus
  5. Labs
    1. Complete Blood Count (CBC)
      1. Leukocytosis
    2. Wound smear
      1. Gram Positive encapsulated rods
  6. Imaging
    1. Air in fascial plains
  7. Management
    1. Extensive debridement
    2. Penicillin G 20 Million U qd
    3. If Penicillin allergic, then check sensitivities on:
      1. Chloramphenicol 4 g qd
      2. Cefoxitin
      3. Clindamycin
      4. Metronidazole
    4. Consider hyperbaric oxygen chamber

Clostridium perfringens (bacteria) (C0009063)

Definition (NCI) Any bacterial organism that can be assigned to the species Clostridium perfringens.
Definition (NCI) A species of anaerobic, Gram positive, rod shaped bacteria assigned to the phylum Proteobacteria. This species is motile, hydrolyzes gelatin, produces enterotoxin, is beta-hemolytic and catalase negative. C. perfringens is a food borne pathogen, being the causative agent of pig-bel syndrome and gas gangrene.
Definition (MSH) The most common etiologic agent of GAS GANGRENE. It is differentiable into several distinct types based on the distribution of twelve different toxins.
Definition (CSP) most common etiologic agent of gas gangrene; differentiable into several distinct types based on the distribution of twelve different toxins.
Concepts Bacterium (T007)
MSH D003016
SnomedCT 8331005
English Clostridium perfringens, Clostridium welchii, Clostridium plagarum, Clostridium perfringens (bacteria), C. perfringens, Clostridium perfringens (Veillon and Zuber 1898) Hauduroy et al. 1937, CLOSTRIDIUM PERFRINGENS, CLOSTRIDIUM WELCHII, clostridium perfringens, clostridium welchii, c. perfringens, perfringens clostridium, Bacillus perfringens, Bacterium welchii, Gas bacillus, Welchia perfringens, Clostridium perfringens (organism)
Swedish Clostridium perfringens
Czech Clostridium perfringens
Finnish Clostridium perfringens
Italian Clostridium welchii, Clostridium perfringens
Japanese クロストリジウム･パーフリンジェンス, Welch菌, ウェルシュ菌
Polish Laseczki zgorzeli gazowej, Clostridium perfringens, Laseczki Welcha
Spanish Clostridium perfringens (organismo), Clostridium perfringens, Clostridium welchii
French Clostridium perfringens, Clostridium welchii
German Clostridium perfringens, Clostridium welchii
Russian CLOSTRIDIUM PERFRINGENS, BACILLUS PERFRINGENS, BACTERIUM WELCHII
Dutch Clostridium perfringens, Clostridium welchii, Gasgangreenbacterie
Portuguese Clostridium perfringens, Clostridium welchii
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Gas Gangrene (C0017105)

Definition (MSH) A severe condition resulting from bacteria invading healthy muscle from adjacent traumatized muscle or soft tissue. The infection originates in a wound contaminated with bacteria of the genus CLOSTRIDIUM. C. perfringens accounts for the majority of cases (over eighty percent), while C. noyvi, C. septicum, and C. histolyticum cause most of the other cases.
Concepts Disease or Syndrome (T047)
MSH D005738
ICD9 040.0
ICD10 A48.0
SnomedCT 276198000, 186413007, 80466000, 186407003
English Gangrene, gas, Gangrenes, Gas, Gas Gangrene, Gas Gangrenes, GANGRENE, GAS, Gangrene, Gas, Gas gangrene due to Clostridia, NOS, Gas gangrene, NOS, CLOSTRIDIAL MYONECROSIS <GAS GANGRENE>, clostridial myonecrosis (diagnosis), clostridial myositis, clostridial myonecrosis, clostridial myositis (diagnosis), Gas bacillus infection (disorder), gas gangrene (diagnosis), malignant edema (diagnosis), malignant edema, gas gangrene, gangrene due to gas, GANGRENE GAS, CLOSTRIDIAL MYONECROSIS GAS GANGRENE, Gas Gangrene [Disease/Finding], gangrene gas, Progressive emphysematous necrosis, Gas gangrene, Clostridial myonecrosis, Clostridial myositis, Gas bacillus infection, Malignant edema, Malignant oedema, Gas gangrene (disorder), Gas gangrene due to Clostridia, gangrene; gas gangrene, gangrene; gas, gas; gangrene, myonecrosis; Clostridium, Clostridium; gas-forming, Clostridial myositis as a result of gas gangrene, Gas bacillus infection or gangrene
Japanese ガス壊疽, ｶﾞｽｴｿ
Swedish Gasgangrän
Czech gangréna plynatá, Plynatá gangréna
Spanish Gas gangrene, Gas bacillus infection, edema maligno, gangrena gaseosa (trastorno), gangrena gaseosa por Clostridium, gangrena gaseosa, infección por bacilo gaseoso, mionecrosis por Clostridium, miositis clostridial, Gangrena gaseosa, Gangrena Gaseosa
Finnish Kaasukuolio
Russian GANGRENA GAZOVAIA, ГАНГРЕНА ГАЗОВАЯ
German Gasbrand [Gasoedem], Gasgangraen, Gangrän, Gas-, Gasgangrän
Korean 가스 괴저
Polish Zakażenie przyranne, Zgorzel gazowa, Obrzęk złośliwy, Zakażenie Clostridium perfringens
Hungarian gáz gangraena
Dutch Clostridium; gasvormend, gangreen; gasgangreen, gangreen; gas, gas; gangreen, myonecrose; Clostridium, gasgangreen, Gangreen, gas-, Gasgangreen
Portuguese Gangrena gasosa, Gangrena Gasosa
French Gangrène gazeuse
Italian Gangrena gassosa
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Anaerobic cellulitis (C0241828)

Concepts Disease or Syndrome (T047)
SnomedCT 238401006
English CELLULITIS, ANAEROBIC, Anaerobic cellulitis, Anaerobic cellulitis (disorder), cellulitis; anaerobic, anaerobic; cellulitis
Dutch anaëroob; cellulitis, cellulitis; anaëroob
Spanish celulitis anaeróbica (trastorno), celulitis anaeróbica, celulitis por anaerobios
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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