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EzetimibeAka: Zetia
- Indications
- Hyperlipidemia monotherapy
- Hyperlipidemia combination therapy
- Adjunct to Statin agents in multi-drug regimen
- Homozygous Sitosterolemia
- Mechanism: Cholesterol absorption inhibitor
- Class: 2-Azetidinone
- Blocks Cholesterol absorption from diet and bile acids
- Selective Cholesterol absorption inhibitor
- Inhibits absorption at small intestine brush border
- Adverse effects
- Minimal adverse effects due to minimal absorption
- Efficacy
- Triglyceride levels did not change significantly
- LDL Cholesterol reduced 17%
- HDL Cholesterol increased 1.3%
- References
- Dujovne (2002) Am J Cardiol 90:1092
- Dosing: Adults and Children over age 10 years
- Ezetimibe 10 mg PO qd
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