Cardiovascular Medicine Book

Congestive Heart Failure

Coronary Artery Disease

Electrocardiogram

Examination

Hyperlipidemia

Hypertension

Miscellaneous

Pericardial Disorders

Obstetrics Chapter related topics

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EzetimibeAka: Zetia

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  1. Indications
    1. Hyperlipidemia monotherapy
    2. Hyperlipidemia combination therapy
      1. Adjunct to Statin agents in multi-drug regimen
    3. Homozygous Sitosterolemia
  2. Mechanism: Cholesterol absorption inhibitor
    1. Class: 2-Azetidinone
    2. Blocks Cholesterol absorption from diet and bile acids
    3. Selective Cholesterol absorption inhibitor
      1. Inhibits absorption at small intestine brush border
  3. Adverse effects
    1. Minimal adverse effects due to minimal absorption
  4. Efficacy
    1. Triglyceride levels did not change significantly
    2. LDL Cholesterol reduced 17%
    3. HDL Cholesterol increased 1.3%
    4. References
      1. Dujovne (2002) Am J Cardiol 90:1092
  5. Dosing: Adults and Children over age 10 years
    1. Ezetimibe 10 mg PO qd

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