Rabeprazole

Aka: Rabeprazole, Aciphex

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II. Indications

  1. Peptic Ulcer Disease
  2. Gastroesophageal Reflux
  3. Erosive Esophagitis
  4. Zollinger-Ellison Syndrome

III. Contraindications

  1. Hypersensitivity to Proton Pump Inhibitors
  2. Use with caution in severe liver disease

IV. Dosing: Adult

  1. See Helicobacter Pylori Treatment
  2. Background
    1. May take regardless of food timing
    2. When using for Helicobacter Pylori, take with meals
  3. Gastroesophageal Reflux
    1. Take 20 mg orally daily for 4 to 16 weeks
  4. Duodenal Ulcer
    1. Take 20 mg orally daily for 4 weeks
  5. Zollinger Ellison Syndrome
    1. Take 60 mg orally daily (up to twice daily)

V. Dosing: Child

  1. Age 1 to 11 years
    1. Weight <15 kg: Give 5 mg orally once daily (maximum 10 mg/day) for up to 8 weeks
    2. Weight >15 kg: Give 10 mg orally once daily for up to 8 weeks
  2. Age >=12 years
    1. Give 20 mg orally daily for up to 8 weeks

VI. Pharmacokinetics

  1. All PPIs have short plasma half life of 1-2 hours
  2. Effect is delayed 5-7 days until proton pumps are fully blocked
  3. Metabolized by CYP2C19 and CYP3A4

VII. Mechanism

  1. See Proton Pump Inhibitor

VIII. Adverse Effects:

  1. See Proton Pump Inhibitor

IX. Precautions

  1. See Proton Pump Inhibitor

X. Safety

  1. Pregnancy Category B
  2. Unknown safety in Lactation

XI. Efficacy

  1. See Proton Pump Inhibitor

XII. Drug Interactions

  1. See Proton Pump Inhibitor

XIII. Resources

  1. Rabeprazole (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=14412af6-e99c-4264-bc34-28a6f139f252

XIV. References

  1. (2022) Comparison of Proton Pump Inhibitors, Presc Lett, #380327
  2. (2012) Prescr Lett 19(3): 14 [PubMed]
  3. (2013) Prescr Lett 20(5): 30 [PubMed]
  4. (2001) Med Lett Drugs Ther 43(1103):36-7 [PubMed]
  5. Ament (2012) Am Fam Physician 86(1): 66-70 [PubMed]
  6. Vanderhoff (2002) Am Fam Physician 66(2):273-80 [PubMed]

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Related Studies

Cost: Medications

rabeprazole (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
RABEPRAZOLE SOD DR 20 MG TAB Generic $0.20 each
aciphex (on 9/1/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
ACIPHEX DR 20 MG TABLET Generic $0.20 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

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