II. Indications
- Peptic Ulcer Disease
- Gastroesophageal Reflux
- Erosive Esophagitis
- Zollinger-Ellison Syndrome
III. Contraindications
- Hypersensitivity to Proton Pump Inhibitors
- Use with caution in severe liver disease
IV. Dosing: Adult
- See Helicobacter Pylori Treatment
- Background
-
Duodenal Ulcer or erosive Esophagitis
- Take 40 mg orally daily
- Zollinger Ellison Syndrome
- Take 40 mg orally twice daily OR
- Administer 80 mg IV every 8 to 12 hours until taking oral medications
V. Dosing: Child
- Indicated in GERD with erosive eosphagitis
- Weight <15 kg (off-label)
- Give 0.5 to 1 mg/kg/day
- Weight 15 to 40 kg
- Give 20 mg orally daily for up to 8 weeks
- Weight >=40 kg
- Give 40 mg orally daily for up to 8 weeks
VI. Pharmacokinetics
- All PPIs have short plasma half life of 1-2 hours
- Effect is delayed 5-7 days until proton pumps are fully blocked
- Metabolized by CYP2C19
VII. Mechanism
VIII. Adverse Effects:
IX. Precautions
X. Safety
- Pregnancy Category B
- Unknown safety in Lactation
XI. Efficacy
XII. Drug Interactions
XIII. Resources
- Pantoprazole (DailyMed)
XIV. References
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Related Studies
| pantoprazole (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| PANTOPRAZOLE 40 MG SUSPENSION | Generic | $9.18 each |
| PANTOPRAZOLE DR 40 MG SUSP PKT | Generic | $10.58 each |
| PANTOPRAZOLE SOD DR 20 MG TAB | Generic | $0.05 each |
| PANTOPRAZOLE SOD DR 40 MG TAB | Generic | $0.06 each |
| protonix (on 1/1/2023 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| PROTONIX 40 MG SUSPENSION | Generic | $11.98 each |
| PROTONIX DR 40 MG TABLET | Generic | $0.06 each |