Drug-Induced Olfactory Dysfunction

Aka: Drug-Induced Olfactory Dysfunction, Drug-Induced Gustatory Dysfunction, Altered Sensation of Smell due to Medication, Medication Causes of Disordered Sense of Smell, Medication Causes of Disordered Sense of Taste

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II. Causes: Cardiovascular

  1. Angiotensin-Converting Enzyme Inhibitor (ACE Inhibitor)
  2. Angiotensin Receptor Blocker (ARB)
  3. Dihydropyridine Calcium Channel Blocker
  4. Diuretics
  5. Antiarrhythmics
  6. Lipid lowering agents

III. Causes: Nasal Preparations

  1. Intranasal Zinc
  2. Nasal Sprays in general

IV. Causes: Antimicrobials

  1. Antibiotics
    1. Penicillin
    2. Tetracycline
    3. Metronidazole (Flagyl)
    4. Macrolides (e.g. Clarithromycin, Azithromycin, Erythromycin)
    5. Fluoroquinolone (e.g. Ciprofloxacin, Levofloxacin)
    6. Aminoglycosides
  2. Antifungals
    1. Terbinafine (Lamasil)
    2. Griseofulvin
  3. HIV Medications
    1. Protease Inhibitors

V. Causes: Miscellaneous

  1. Chemotherapy
    1. Antiproliferative drugs (e.g. Cisplatin)
  2. Antirheumatic Drugs (e.g. Penicillamine)
  3. Antithyroid Medications
  4. Antidepressants
  5. Anticonvulsants
  6. Azelastine (Antihistamine)
  7. Zopiclone (for Insomnia)

VI. References

  1. Ackerman (1997) Pharmacotherapy 17(3): 482-96 [PubMed]
  2. Malaty (2013) Am Fam Physician 88(1): 852-9 [PubMed]
  3. Naik (2010) Eur J Intern Med 21(3): 240-3 [PubMed]

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