Aminoglycoside

Aka: Aminoglycoside, Gentamicin, Garamycin

advertisement

II. Pharmacokinetics

  1. Maintain Trough <2 ug/ml
    1. Drawn immediately before next dose
  2. Maintain Peak at 5-8 ug/ml (4-6 ug/ml for child)
    1. Draw 1 hour after Intramuscular dose
  3. Indications for Pharmacokinetics followed by PharmD
    1. Aminoglycoside use over 3 days
    2. Renal dysfunction

III. Precautions

  1. Administer IV dose over 1 hour
  2. Adjust dosing per kinetics if >1-2 days use
  3. Aminoglycosides are associated with risk of Ototoxicity and nephrotoxicity (FDA black box warning)

IV. Dosing: Infants

  1. Term Infant
    1. Gentamycin 2.5 mg/kg/dose IV or IM q8 hours
  2. Preterm Infant
    1. Gestational age >34 weeks and Weight over 2000 grams
      1. Gentamycin 2.5 mg/kg/dose IV or IM q12 hours
    2. Gestational age <34 weeks
      1. Weight over 1250 grams
        1. Gentamycin 2.5 mg/kg/dose IV or IM q18 hours
      2. Weight Under 1250 grams
        1. Gentamycin 2.5 mg/kg/dose IV or IM q24 hours
    3. Age >7 days
      1. Gentamycin 2.5 mg/kg/dose IV or IM q12 hours
  3. Renal Impairment Adjustments
    1. Serum Creatinine 0.7 to 1.1
      1. Gentamycin 2.5 mg/kg/dose IV or IM q24 hours
    2. Serum Creatinine 1.1 to 1.3
      1. Gentamycin 2.5 mg/kg/dose IV or IM q36 hours
    3. Serum Creatinine > 1.3
      1. Gentamycin 2.5 mg/kg/dose IV or IM q48 hours

V. Dosing: Children and adults

  1. Child
    1. Gentamicin 2 to 2.5 mg/kg IV or IM q8 hours
    2. Gentamicin 4.5 mg/kg IV q24 hours
  2. Adults
    1. Gentamicin 1-1.5 mg/kg IV or IM q8 hours or
    2. Gentamicin 5-7 mg/kg IV q24 hours

VI. Risk Factors for Nephrotoxicity

  1. Advanced age
  2. Prior Renal Insufficiency
  3. Dehydration
  4. Hypokalemia
  5. Hypomagnesemia
  6. Liver disease
  7. Sepsis
  8. Drug Interactions with other nephrotoxic medications
    1. Cephalothin (Keflin) and other Cephalosporins
    2. Cyclosporin A
    3. Cisplatin
    4. NSAIDS
    5. ACE Inhibitors
    6. Methoxyflurane
    7. Loop Diuretics
    8. Amino Acids

Images: Related links to external sites (from Bing)

These images are a random sampling from a Bing search on the term "Aminoglycoside." Click on the image (or right click) to open the source website in a new browser window. Search Bing for all related images

Related Studies

Cost: Medications

gentamicin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
GENTAMICIN 0.1% CREAM Generic $1.07 per gram
GENTAMICIN 0.1% OINTMENT Generic $1.22 per gram
GENTAMICIN 0.3% EYE DROP Generic $0.72 per ml
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Pharmacology

advertisement