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Propofol Infusion Syndrome

Aka: Propofol Infusion Syndrome
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  1. See Also
    1. Propofol
    2. Fospropofol
  2. Epidemiology
    1. ICU patients (most common)
    2. Patients on backboard in Emergency Department
  3. Pathophysiology
    1. Propofol infusion results in mitochondrial respiration arrest
      1. Especially with infusion doses >4 mg/kg/hour or infusion duration >48 hours
      2. Has occurred with durations as short as 24 hours
  4. Risk Factors
    1. Young patients
    2. Sepsis
    3. Concurrent pressor or glucocorticoid administration
  5. Signs
    1. Metabolic Acidosis
    2. Lactic Acidosis
    3. Rhabdomyolysis
    4. Dysrhythmias
      1. Bradycardia
      2. Ventricular Tachycardia
      3. Asystole
  6. Management
    1. Supportive care
    2. Hemodialysis if Acute Renal Failure occurs
  7. Prognosis
    1. High mortality rate
  8. References
    1. Majoewsky (2012) EM:RAP 12(1): 3

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