II. Mechanism

  1. Mu-Opioid receptor agonist
  2. Norepinephrine reuptake inhibitor

III. Indications

  1. Moderate to severe acute pain

IV. Contraindications

  1. Severe renal Impairment
  2. Severe hepatic Impairment

V. Efficacy

  1. As effective as Oxycodone
  2. Less Nausea, Vomiting and Constipation than Oxycodone

VI. Drug Interactions

VII. Adverse Reactions

  1. Seizures
  2. Anaphylactoid Reaction
  3. Respiratory Depression

VIII. Preparations

  1. Schedule II Controlled Substance
  2. Immediate release
    1. Tapentadol 50-100 mg orally every 4-6 hours as needed (up to 600 mg/day)
    2. Decrease dose to 50 mg every 8 hours if moderate hepatic Impairment
  3. Extended release
    1. Tapentadol XR 50 mg orally twice daily (and titrate up to 250 mg twice daily)
    2. May start higher if transitioning from other Opioids

IX. References

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Cost: Medications

nucynta (on 4/19/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
NUCYNTA 100 MG TABLET $7.89 each
NUCYNTA 50 MG TABLET $5.06 each
NUCYNTA 75 MG TABLET $5.90 each
NUCYNTA ER 100 MG TABLET $10.13 each
NUCYNTA ER 150 MG TABLET $13.04 each
NUCYNTA ER 200 MG TABLET $16.63 each
NUCYNTA ER 250 MG TABLET $20.81 each
NUCYNTA ER 50 MG TABLET $5.49 each

Ontology: tapentadol (C2001271)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C523979
SnomedCT 441757005, 442004000
LNC LP99218-7, MTHU035629
English Tapentadol, Tapentadol (product), Tapentadol (substance), TAPENTADOL, tapentadol, 3-((1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl)phenol
Spanish tapentadol (producto), tapentadol, tapentadol (sustancia)