Obstetrics Book

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OxytocinAka: Pitocin

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  1. Indications
    1. Labor Induction or Labor Augmentation
    2. Prevention of Postpartum Hemorrhage
  2. Adverse effects
    1. Uterine hypertonicity
      1. Uterine tetanic contractions and Fetal Distress
      2. Uterine Rupture
    2. Water intoxication (SIADH)
      1. Associated with slow infusion >24 hours
  3. Pharmacokinetics of intravenous oxytocin
    1. Onset: 1 minute
    2. Duration: 30 minutes
    3. Half-life: <5 minutes
  4. Dosing
    1. See Labor Induction
    2. Postpartum Hemorrhage prevention after vaginal delivery
      1. Oxytocin 10 units IM after delivery
      2. Oxytocin 10-40 units in 1 L IV fluid (NS, LR, D5W)
    3. Postpartum Hemorrhage prevention after cesarean
      1. High dose oxytocin prevents atony
      2. Dose: Oxytocin 2667 mU/min for 30 minutes
      3. Munn (2001) Obstet Gynecol 98:386

Oxytocin (C0030095)

Definition (MSH)A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on smooth muscle cells, such as causing UTERINE CONTRACTIONS and MILK EJECTION.
Definition (CSP)peptide hormone produced by the posterior lobe of the pituitary gland that induces contraction of the smooth muscle of the uterus and the myoepithelial cells of the mammary gland.
Definition (NCI)A hormone secreted by the posterior portion of the pituitary gland and stimulates uterine smooth muscle contraction and lactation.
Definition (NCI)Expressed in the hypothalamic supraoptic and paraventricular nuclei as an inactive precursor by human OXT Gene (Vasopressin/Oxytocin Family), 125-aa 13-kDa (precursor) secreted Oxytocin (and Neurophysin I) is a posterior pituitary nonapeptide hormone specifically bound to carrier protein Neurophysin I. Activated during axon transport to nerve endings, Oxytocin is packaged into neurosecretory vesicles, secreted into the neurohypophyseal bloodstream, and causes smooth muscle contraction in the uterus during parturition and in the mammary gland during lactation. Oxytocin is also involved in cognition, tolerance, adaptation, and complex sexual and maternal behavior, as well as in regulation of water excretion and cardiovascular functions.
ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Hormone (T125)
MSHD010121
EnglishOcytocin, OXT, Oxytocin, Oxytocin preparation, Oxytocin product
Spanishocitocina, oxitocina, preparado con ocitocina, preparado con oxitocina, preparado de ocitocina, preparado de oxitocina
Parent ConceptsVasopressin (USP) (C1705480), Posterior Pituitary Hormones (C0032017), reproductive hormone (C0597376), Pituitary Hormones (C0032015), Oxytocics (C0030094), Peptide hormones and their metabolites and precursors (C0582246), Drug allergen (C1320237), Pituitary Hormonal Agents (C1579308), Hormones (C0019932)
SourcesAOD, CSP, LCH, LNC, MSH, MTH, MTHSPL, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, UWDA, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Pitocin (C0733348)

ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Hormone (T125)
MSHD010121
EnglishPitocin
SourcesMSH, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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