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Uterotonic Medication

Indications
1. Postpartum Hemorrhage
Medications
1. Oxytocin (Pitocin)
  1. Onset in 3 to 5 minutes
  2. Intramuscular: 10-20 units
  3. Intravenous: 40 units/liter at 250 cc/hour
2. Ergotamine (Methergine)
  1. Dosing: 0.2 mg IM or PO every 6-8 hours
  2. Onset in 2 to 5 minutes
  3. Contraindications
    1. Hypertension
    2. Pregnancy Induced Hypertension
    3. Hypersensitivity
3. Prostaglandin (Hemabate)
  1. Dosing: 0.25mg Intramuscular or Intra-Myometrium
  2. Onset <5 minutes
  3. Administer every 15 minutes to maximum of 2 mg
4. Misoprostol 600 mcg PO or PR
  1. Khan (2003) Obstet Gynecol 101:968

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 6/1/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.