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GalantamineAka: Reminyl, Razadyne

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  1. See Also
    1. Rivastigmine (Exelon)
    2. Donepezil (Aricept)
  2. Indication
    1. Alzheimer's Disease related Dementia
  3. Mechanism
    1. Acetylcholinesterase inhibitor
    2. Acts also at nicotinic receptors
    3. Derived from Daffodil bulbs
  4. Pharmacokinetics
    1. Half-Life: 7 hours in elderly patients
    2. Metabolized by liver enzymes: CYP2D6 and CYP3A4
  5. Dosing
    1. Initial: 4 mg PO bid with breakfast and dinner x4 weeks
    2. Maintenance: 8 mg PO bid for at least 4 weeks
    3. Consider 12 mg PO bid if indicated
    4. May require concurrent Antiemetic use
  6. Adverse Effects
    1. No hepatic toxicity found (contrast with Tacrine)
    2. Gastrointestinal effects
      1. Nausea or Vomiting
      2. Diarrhea
      3. Anorexia
      4. Weight loss
    3. Cardiovascular effects
      1. Dizziness
      2. Bradycardia
  7. Efficacy
    1. Moderately preserved cognitive function for >6 months
    2. References
      1. Raskind (2000) Neurology 54:2261
      2. Tariot (2000) Neurology 54:2269
  8. Cost
    1. (2003) Red Book: $134/month
  9. References
    1. (2001) Med Lett Drugs Ther 43(1107):53

Galantamine (C0016967)

Definition (MSH)A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishGalantamin, Galantamine, GALANTAMINE PREPARATION, Galanthamine, Lycoremine
Spanishgalantamina
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Reminyl (C0939465)

Definition (MSH)Name of the FDA approved preparation from J&J.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishReminyl
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Razadyne (C1612436)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishRazadyne
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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