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RivastigmineAka: Exelon

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  1. See Also
    1. Tacrine (Cognex)
    2. Donepezil (Aricept)
  2. Indications
    1. Alzheimer's Disease related Dementia
  3. Mechanism
    1. Carbamate-based noncompetitive cholinesterase inhibitor
    2. Inhibits butyrylcholinesterase and acetylcholinesterase
    3. Increases cholinergic transmission
  4. Pharmacokinetics
    1. Peak: 1 hour
    2. Duration: 10 hours
  5. Drug Interactions
    1. No significant drug interactions
  6. Efficacy
    1. Modestly improves scores on neuropsychological tests
    2. Benefits decrease after 40 weeks of treatment
  7. Adverse Effects
    1. Nausea or Vomiting
    2. Diarrhea
    3. Abdominal Pain
    4. Anorexia
    5. Weight loss
    6. No hepatotoxicity risk (contrast with Tacrine)
  8. Dosing
    1. Initial: 1.5 mg PO bid with food
    2. Increase dose by 1.5 mg every 2 weeks up to 6 mg bid
  9. Cost
    1. (2003) Red Book: $130/month
  10. References
    1. (2000) Med Lett Drugs Ther 42(1089):93
    2. Corey-Bloom (1998) Int J Geriatr Psychopharm 1:55
    3. Rosler (1999) BMJ 318:633

rivastigmine (C0649350)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
Englishrivastigmine, RIVASTIGMINE PREPARATION
Spanishrivastigmina
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Exelon (C0730987)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishExelon
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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