II. Indications

  1. Suspected enterovirus Meningitis
    1. Allows for early hospital discharge
  2. Suspected Herpes Simplex VirusEncephalitis
  3. Suspected CytomegalovirusEncephalitis

III. Available PCR tests

  1. Viral Meningitis sensitivity: 95-100%
  2. HSV Type I sensitivity: 100%
  3. Epstein-Barr Virus sensitivity: 100%
  4. Enterovirus sensitivity: 100%
  5. Cytomegalovirus (CMV)
    1. PCR is gold standard
  6. Tuberculosis sensitivity: 54-100%
  7. Acute Neurosyphilis
    1. Lower sensitivity in chronic Neurosyphilis

IV. Advantages

  1. High sensitivity and Specificity
  2. Fast
  3. Requires only small CSF volumes

V. Disadvantages

  1. Expensive

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