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Autonomic DysfunctionAka: Dysautonomia, Autonomic Neuropathy, Chronic Autonomic Neuropathy

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  1. Types: Chronic Autonomic Failure
    1. Orthostatic Hypotension
      1. Diabetes Mellitus
      2. Amyloidosis
      3. Tabes dorsalis
      4. Multiple Sclerosis
      5. Acute Intermittent Porphyria
      6. Guillain-Barre Syndrome
      7. Toxins
        1. Vacor rat poison
        2. Arsenic
        3. Mercury
      8. Renal Failure
      9. Medications
      10. See Autonomic Neuropathy
    2. Primary Chronic Autonomic Failure (Idiopathic)
      1. Pure autonomic failure
      2. Multiple system atrophy
      3. Parkinson's Disease
    3. Chronic Orthostatic Intolerance
      1. Example: Neuropathic postural tachycardia syndrome
    4. Other causes
      1. Panic Disorder (psychogenic Ischemic Heart Disease)
      2. Neurogenic Essential Hypertension
      3. Congestive Heart Failure
      4. Chronic Fatigue Syndrome
  2. Symptoms and Signs
    1. Postural Hypotension
    2. Nocturnal Diarrhea
    3. Impotence
    4. Incomplete voiding
  3. Diagnostics: Telemetry monitoring
    1. No overshoot tachycardia on standing
    2. No variation in pulse with Valsalva maneuver
    3. No Blood Pressure (<10 mmHg) increase with hand grip
  4. Management: Orthostatic Hypotension
    1. See Vasovagal Syncope for assessment and management
  5. References
    1. Pryse-Phillips in Noble (2001) Primary Care, p. 1599
    2. Saper in Goldman (2000) Cecil Medicine, p. 2057-8
    3. Goldstein (2002) Ann Intern Med 137:753

Dysautonomia (C0013363)

Definition (NCI)An acute or chronic disorder, affecting the sympathetic or parasympathetic nervous system. It can be primary, the result of central nervous system degeneration, or secondary due to diabetes or alcoholism. Patients with the chronic form of this disorder usually have a progressive clinical course and a poor prognosis.
ConceptsDisease or Syndrome (T047)
MSHD001342
EnglishDysautonomia, Dysautonomias
Spanishdisautonomia
Parent ConceptsAutonomic nervous system (C0004388), Autonomic nervous system disorders (C1145628), Non-Neoplastic Peripheral Nervous System Disorder (C1335029)
SourcesCST, MSH, MTH, NCI, OMIM, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Autonomic neuropathy (C0259749)

ConceptsDisease or Syndrome (T047)
EnglishAutonomic neuropathy
Spanishneuropatia autonoma
Parent ConceptsNeuropathy (C0442874), Autonomic nervous system disorders (C1145628)
SourcesCOSTAR, CSP, NCI, QMR, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Autonomic nervous system disorders (C1145628)

Definition (MSH)Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
Definition (CSP)condition in which there is a deviation from or interruption of the normal structure or function of the parasympathetic or sympathetic divisions of the autonomic nervous system; autonomic dysfunction may be associated with hypothalamic diseases, brain stem disorders, spinal cord diseases, and peripheral nervous system diseases; manifestations include impairments of vegetative functions including the maintenance of blood pressure, heart rate, pupil function, sweating, reproductive and urinary physiology, and digestion.
ConceptsDisease or Syndrome (T047)
ICD9337, 337.9
MSHD001342
EnglishANS DIS, ANS Disease, ANS Diseases, AUTONOMIC DIS, Autonomic Disease, Autonomic Diseases, autonomic disorder, AUTONOMIC NERVE DIS NEC, AUTONOMIC NERVOUS DISORDERS, AUTONOMIC NERVOUS SYSTEM DIS, Autonomic Nervous System Diseases, autonomic nervous system disorder, Autonomic nervous system disorders, CENTRAL AUTONOMIC NERVOUS SYSTEM DIS, Central Autonomic Nervous System Diseases, DIS AUTONOMIC NERVOUS SYSTEM, Disorder of autonomic nervous system, Disorder of vegetative system, Disorders of autonomic nervous system, Disorders of the autonomic nervous system, NERVOUS SYSTEM DIS AUTONOMIC, Unspecified disorder of autonomic nervous system
Spanishtrastorno del sistema nervioso autonomico, trastorno del sistema nervioso autonomo, trastorno del sistema vegetativo
Parent ConceptsOther hereditary and degenerative nervous system conditions (C0809991), nervous system disorder (C0027765), COSTART (C1140097), Autonomic nervous system disorders (C1145628), Hereditary AND/OR degenerative disease of central nervous system (C1444208), Peripheral Neuropathy (C0031117)
SourcesCCS, CSP, CST, ICD9CM, MSH, MTH, NDFRT, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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