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Danazol
- Indications
- Endometriosis
- Pathophysiology
- Synthetic isoxazol derivative of ethisterone
- Inhibits gonadotropic secretion
- Prevents Menstrual Bleeding
- Mildly androgenic
- Dosing
- Danazol 400-600 mg qd
- Efficacy
- Expensive ($100/month)
- Same rate of pregnancy as with Provera or Surgery
- Adverse Effects: Androgenic effects
- Acne Vulgaris
- Flushes
- Sweats
- Edema
- Libido changes
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| Definition (MSH) | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. |
| Definition (NCI) | A synthetic hormone that belongs to the family of drugs called androgens and is used to treat endometriosis. It is being evaluated in the treatment of endometrial cancer. |
| Definition (PDQ) | A synthetic androgen derived from ethinyl testosterone. Danazol indirectly reduces estrogen production by decreasing pituitary secretion of follicle-stimulating hormone and luteinizing hormone, and binds to sex hormone receptors in target tissues, thereby exhibiting antiestrogenic, anabolic and weakly androgenic effects. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39204&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39204&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C414" NCI Thesaurus) |
| Definition (NCI) | A synthetic androgen derived from ethinyl testosterone. Danazol indirectly reduces estrogen production by decreasing pituitary secretion of follicle-stimulating hormone and luteinizing hormone, and binds to sex hormone receptors in target tissues, thereby exhibiting antiestrogenic, anabolic and weakly androgenic effects. (NCI04) |
| Concepts | Steroid (T110)
, Pharmacologic Substance (T121)
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| English | DAN, Danazol, Danazol preparation, Danazol product |
| Spanish | danazol, preparado con danazol, preparado de danazol |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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